Pregnancy in patients with well-treated β-thalassemia: Outcome for mothers and newborn infants

Objective: Our purpose was to investigate the course and outcome of pregnancy in women with well-treated β-thalassemia. Study Design: Twenty-two pregnancies, including one twin pregnancy, in 19 women were studied. Pregnancy was advised when patients had received a prolonged intensive treatment with...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 1999-02, Vol.180 (2), p.360-365
Main Authors: Aessopos, Athanasios, Karabatsos, Fotis, Farmakis, Dimitrios, Katsantoni, Aspassia, Hatziliami, Antonia, Youssef, Jacqueline, Karagiorga, Markisia
Format: Article
Language:English
Subjects:
Adult
beta-Thalassemia - complications
beta-Thalassemia - physiopathology
beta-Thalassemia - therapy
Biological and medical sciences
Blood Transfusion
cardiac function
Cesarean Section
deferoxamine
Diseases of mother, fetus and pregnancy
Electrocardiography
Female
fertility
Gynecology. Andrology. Obstetrics
Heart - physiopathology
Heart Rate
Hemodynamics
Humans
Infant, Newborn
Iron Chelating Agents - therapeutic use
Liver - physiopathology
Male
Medical sciences
Pregnancy
Pregnancy Complications, Hematologic
Pregnancy Outcome
Pregnancy. Fetus. Placenta
Thalassemia
Ventricular Function, Left
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Summary:Objective: Our purpose was to investigate the course and outcome of pregnancy in women with well-treated β-thalassemia. Study Design: Twenty-two pregnancies, including one twin pregnancy, in 19 women were studied. Pregnancy was advised when patients had received a prolonged intensive treatment with hypertransfusions and iron chelation and had echocardiographically normal resting left ventricular performance. All conceptions were spontaneous. Cardiac function, along with hematologic, endocrinologic, and hepatic parameters were initially assessed and monitored throughout pregnancy and for 2 to 9 years post partum. Babies were delivered by elective cesarean section. Results: Twenty-one healthy newborn infants were delivered. A spontaneous abortion and a case of exomphalos also occurred. Gestation, delivery, and recovery were surprisingly uneventful, and no significant cardiac complications were encountered. Conclusion: Pregnancy can be safe for mothers and babies, provided that women with thalassemia have been started early on intensive treatment and have a normal resting cardiac performance. (Am J Obstet Gynecol 1999;180:360-5.)
ISSN:0002-9378
1097-6868
DOI:10.1016/S0002-9378(99)70214-0