IFN Consensus Sequence Binding Protein (Icsbp) Is Critical for Eosinophil Development

IFN consensus sequence binding protein (Icsbp) (IFN response factor-8) is a hematopoietic transcription factor with dual functions in myelopoiesis and immunity. In this study, we report a novel role of Icsbp in regulating the development of eosinophils. Loss of Icsbp in mice leads to a reduction of...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2008-10, Vol.181 (7), p.5045-5053
Main Authors: Milanovic, Maja, Terszowski, Grzegorz, Struck, Daniela, Liesenfeld, Oliver, Carstanjen, Dirk
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation - genetics
Cell Differentiation - immunology
Cells, Cultured
Consensus Sequence - genetics
Consensus Sequence - immunology
Eosinophilia - genetics
Eosinophilia - immunology
Eosinophilia - parasitology
Eosinophils - immunology
Eosinophils - metabolism
Eosinophils - parasitology
Eosinophils - pathology
Interferon Regulatory Factors - deficiency
Interferon Regulatory Factors - genetics
Interferon Regulatory Factors - physiology
Leukocyte Count
Mice
Mice, Inbred C57BL
Mice, Knockout
Nippostrongylus - immunology
Rats
Rats, Inbred Lew
Strongylida Infections - genetics
Strongylida Infections - immunology
Strongylida Infections - pathology
Transcription, Genetic - immunology
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Summary:IFN consensus sequence binding protein (Icsbp) (IFN response factor-8) is a hematopoietic transcription factor with dual functions in myelopoiesis and immunity. In this study, we report a novel role of Icsbp in regulating the development of eosinophils. Loss of Icsbp in mice leads to a reduction of eosinophils in different tissues. During parasite infection with the nematode Nippostrongylus brasiliensis, Icsbp-deficient mice fail to mount eosinophilia despite a vigorous IL-5 response. Numbers of phenotypically defined eosinophil progenitors are decreased and those progenitors have, on a per-cell basis, reduced eosinophil differentiation potential. The transcription factor Gata1, crucial for eosinophil development, is reduced expressed in committed eosinophil progenitors in wells as mature eosinophils. These findings identify Icsbp as a novel transcription factor critical for the development of the eosinophil lineage.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.181.7.5045