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IFN Consensus Sequence Binding Protein (Icsbp) Is Critical for Eosinophil Development

IFN consensus sequence binding protein (Icsbp) (IFN response factor-8) is a hematopoietic transcription factor with dual functions in myelopoiesis and immunity. In this study, we report a novel role of Icsbp in regulating the development of eosinophils. Loss of Icsbp in mice leads to a reduction of...

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Published in:	The Journal of immunology (1950) 2008-10, Vol.181 (7), p.5045-5053
Main Authors:	Milanovic, Maja, Terszowski, Grzegorz, Struck, Daniela, Liesenfeld, Oliver, Carstanjen, Dirk
Format:	Article
Language:	English
Subjects:	Animals Cell Differentiation - genetics Cell Differentiation - immunology Cells, Cultured Consensus Sequence - genetics Consensus Sequence - immunology Eosinophilia - genetics Eosinophilia - immunology Eosinophilia - parasitology Eosinophils - immunology Eosinophils - metabolism Eosinophils - parasitology Eosinophils - pathology Interferon Regulatory Factors - deficiency Interferon Regulatory Factors - genetics Interferon Regulatory Factors - physiology Leukocyte Count Mice Mice, Inbred C57BL Mice, Knockout Nippostrongylus - immunology Rats Rats, Inbred Lew Strongylida Infections - genetics Strongylida Infections - immunology Strongylida Infections - pathology Transcription, Genetic - immunology
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creator	Milanovic, Maja Terszowski, Grzegorz Struck, Daniela Liesenfeld, Oliver Carstanjen, Dirk
description	IFN consensus sequence binding protein (Icsbp) (IFN response factor-8) is a hematopoietic transcription factor with dual functions in myelopoiesis and immunity. In this study, we report a novel role of Icsbp in regulating the development of eosinophils. Loss of Icsbp in mice leads to a reduction of eosinophils in different tissues. During parasite infection with the nematode Nippostrongylus brasiliensis, Icsbp-deficient mice fail to mount eosinophilia despite a vigorous IL-5 response. Numbers of phenotypically defined eosinophil progenitors are decreased and those progenitors have, on a per-cell basis, reduced eosinophil differentiation potential. The transcription factor Gata1, crucial for eosinophil development, is reduced expressed in committed eosinophil progenitors in wells as mature eosinophils. These findings identify Icsbp as a novel transcription factor critical for the development of the eosinophil lineage.
doi_str_mv	10.4049/jimmunol.181.7.5045
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In this study, we report a novel role of Icsbp in regulating the development of eosinophils. Loss of Icsbp in mice leads to a reduction of eosinophils in different tissues. During parasite infection with the nematode Nippostrongylus brasiliensis, Icsbp-deficient mice fail to mount eosinophilia despite a vigorous IL-5 response. Numbers of phenotypically defined eosinophil progenitors are decreased and those progenitors have, on a per-cell basis, reduced eosinophil differentiation potential. The transcription factor Gata1, crucial for eosinophil development, is reduced expressed in committed eosinophil progenitors in wells as mature eosinophils. 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subjects	Animals Cell Differentiation - genetics Cell Differentiation - immunology Cells, Cultured Consensus Sequence - genetics Consensus Sequence - immunology Eosinophilia - genetics Eosinophilia - immunology Eosinophilia - parasitology Eosinophils - immunology Eosinophils - metabolism Eosinophils - parasitology Eosinophils - pathology Interferon Regulatory Factors - deficiency Interferon Regulatory Factors - genetics Interferon Regulatory Factors - physiology Leukocyte Count Mice Mice, Inbred C57BL Mice, Knockout Nippostrongylus - immunology Rats Rats, Inbred Lew Strongylida Infections - genetics Strongylida Infections - immunology Strongylida Infections - pathology Transcription, Genetic - immunology
title	IFN Consensus Sequence Binding Protein (Icsbp) Is Critical for Eosinophil Development
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