CGRP Activates Renal Pelvic Substance P Receptors by Retarding Substance P Metabolism

Substance P and calcitonin gene-related peptide (CGRP) are colocalized in renal pelvic sensory nerves. Increasing renal pelvic pressure results in an increase in afferent renal nerve activity that is blocked by a substance P receptor antagonist but not by a CGRP receptor antagonist. CGRP potentiates...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1999-01, Vol.33 (1S Suppl), p.493-498
Main Authors: Gontijo, Jose R, Smith, Lori A, Kopp, Ulla C
Format: Article
Language:English
Subjects:
Afferent Pathways - drug effects
Afferent Pathways - physiology
Animals
Biological and medical sciences
Calcitonin Gene-Related Peptide - pharmacology
Fundamental and applied biological sciences. Psychology
Indoles - pharmacology
Isoindoles
Kidney - innervation
Kidney Pelvis - drug effects
Kidney Pelvis - metabolism
Male
Rats
Rats, Sprague-Dawley
Receptors, Neurokinin-1 - drug effects
Receptors, Neurokinin-1 - metabolism
Substance P - metabolism
Thiorphan - pharmacology
Vertebrates: urinary system
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Summary:Substance P and calcitonin gene-related peptide (CGRP) are colocalized in renal pelvic sensory nerves. Increasing renal pelvic pressure results in an increase in afferent renal nerve activity that is blocked by a substance P receptor antagonist but not by a CGRP receptor antagonist. CGRP potentiates the effects of substance P by preventing the metabolism of substance P. Therefore, we examined whether CGRP enhanced the afferent renal nerve activity responses to substance P and increased renal pelvic pressure, a stimulus known to increase substance P release. Combined administration of substance P and CGRP into the renal pelvis resulted in an increase in afferent renal nerve activity (1392 +/- 217% [middle dot] s; area under the curve of afferent renal nerve activity versus time) that was greater (P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.33.1.493