Cold-knife conization versus conization by the loop electrosurgical excision procedure: A randomized, prospective study

Objective: Our purpose was to compare the diagnostic ability and treatment efficacy of conization by the loop electrosurgical excision procedure with cold-knife conization. Study Design: One hundred eighty women who required conization for diagnosis and treatment of cervical dysplasia or microinvasi...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 1999-02, Vol.180 (2), p.276-282
Main Authors: Duggan, Bridgette D., Felix, Juan C., Muderspach, Laila I., Gebhardt, Judith A., Groshen, Susan, Morrow, C.Paul, Roman, Lynda D.
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Adenocarcinoma - surgery
Biological and medical sciences
Biopsy
Cervical Intraepithelial Neoplasia - diagnosis
Cervical Intraepithelial Neoplasia - surgery
Cold-knife conization
Conization - methods
conization by the loop electrosurgical excision procedure
Electrosurgery
Female
Humans
Medical sciences
Neoplasm Recurrence, Local
Postoperative Complications
Prospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the genital tract and mammary gland
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - surgery
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Summary:Objective: Our purpose was to compare the diagnostic ability and treatment efficacy of conization by the loop electrosurgical excision procedure with cold-knife conization. Study Design: One hundred eighty women who required conization for diagnosis and treatment of cervical dysplasia or microinvasive cervical carcinoma were prospectively enrolled in a randomized clinical trial to receive either cold-knife conization or conization by the loop electrosurgical excision procedure. Conization complications, rate of lesion clearance, and therapeutic outcome were assessed for the 2 study groups. Results: There were no statistically significant differences in the complication rate ( P = 1.00), the rate of lesion clearance ( P = .18), or the rate of disease recurrence ( P = .13) between the 2 study groups. The mean follow-up was 11.2 months in the cold-knife conization group and 10.4 months in the loop-excision conization group. Conclusion: Cold-knife conization and loop-excision conization yield similar diagnostic and therapeutic results. (Am J Obstet Gynecol 1999;180:276-82.)
ISSN:0002-9378
1097-6868
DOI:10.1016/S0002-9378(99)70200-0