Doppler sonographic enhancement of hepatic hemangiomas and hepatocellular carcinomas after perflenapent emulsion: preliminary study

Ultrasonographic microbubble contrast agents improve Doppler signals by increasing blood backscatter. We retrospectively reviewed our experience with perflenapent (EchoGen), an emulsion of liquid dodecafluoropentane, in the evaluation of 13 patients with focal hepatic lesions (10 hemangiomas and six...

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Bibliographic Details
Published in:Journal of ultrasound in medicine 1999-02, Vol.18 (2), p.109-116
Main Authors: Lopez-Ben, R, Robbin, M L, Weber, T M, Smith, J K, Needleman, L, Berland, L L
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Blood Flow Velocity
Carcinoma, Hepatocellular - blood supply
Carcinoma, Hepatocellular - diagnostic imaging
Carcinoma, Hepatocellular - physiopathology
Contrast Media - administration & dosage
Diagnosis, Differential
Digestive system. Abdomen
Emulsions
Female
Fluorocarbons - administration & dosage
Follow-Up Studies
Hemangioma, Cavernous - blood supply
Hemangioma, Cavernous - diagnostic imaging
Hemangioma, Cavernous - physiopathology
Hepatic Artery - diagnostic imaging
Hepatic Veins - diagnostic imaging
Humans
Image Enhancement - methods
Injections, Intravenous
Investigative techniques, diagnostic techniques (general aspects)
Liver Neoplasms - blood supply
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - physiopathology
Male
Medical sciences
Middle Aged
Retrospective Studies
Ultrasonic investigative techniques
Ultrasonography, Doppler, Color
Citations: Items that cite this one
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Description
Summary:Ultrasonographic microbubble contrast agents improve Doppler signals by increasing blood backscatter. We retrospectively reviewed our experience with perflenapent (EchoGen), an emulsion of liquid dodecafluoropentane, in the evaluation of 13 patients with focal hepatic lesions (10 hemangiomas and six hepatocellular carcinomas). Perflenapent improved the detection of color Doppler flow signals within the lesions. The hemangiomas showed peripheral nonpulsatile signals and the hepatocellular carcinomas showed more diffuse enhancement with both arterial and venous type signals. This preliminary study suggests that perflenapent administration may aid in the sonographic differentiation of these focal lesions.
ISSN:0278-4297
1550-9613
DOI:10.7863/jum.1999.18.2.109