Antiprotozoal activity of (8-hydroxymethylen)-trieicosanyl acetate isolated from Senna villosa

A white solid compound was isolated from the chloroform extract of the leaves of Senna villosa. The material was identified by 1H-NMR, 13C-NMR, IR and EM methods as (8-hydroxymethylen)-trieicosanyl acetate, a new compound with biological activity, which was tested in vitro at concentrations of 1.65,...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2008-10, Vol.15 (10), p.892-895
Main Authors: Guzmán, E., Pérez, C., Zavala, M.A., Acosta-Viana, K.Y., Pérez, S.
Format: Article
Language:English
Subjects:
(8-hydroxymethylen)-trieicosanyl acetate
Acetates - isolation & purification
Acetates - pharmacology
Animals
Antiprotozoal activity
Antiprotozoal Agents - isolation & purification
Antiprotozoal Agents - pharmacology
Care and treatment
Chemical properties
Control
Dose-Response Relationship, Drug
Eicosanoids - isolation & purification
Eicosanoids - pharmacology
Fabaceae - chemistry
Health aspects
Magnetic Resonance Spectroscopy
Plant Leaves - chemistry
Senna
Senna villosa
Spectrophotometry, Infrared
Trypanosoma cruzi - chemistry
Trypanosomiasis
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Summary:A white solid compound was isolated from the chloroform extract of the leaves of Senna villosa. The material was identified by 1H-NMR, 13C-NMR, IR and EM methods as (8-hydroxymethylen)-trieicosanyl acetate, a new compound with biological activity, which was tested in vitro at concentrations of 1.65, 3.3 and 6.6 μg/ml for inhibition of the growth of Trypanosoma cruzi epimastigotes and tripomastigotes. We observed inhibition of growth at all concentrations tested, and the effect at concentrations of 3.3 and 6.6 μg/ml was greater than that of gentian violet (positive control). At the concentration of 6.6 μg/ml, the compound showed the greatest inhibitory effect against the growth of both forms of the parasite.
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2008.02.013