Systemic lupus erythematosus and multiple myeloma : an uncommon association. Two cases and literature review

The association of systemic lupus erythematosus and multiple myeloma is uncommon. We report two cases of systemic lupus erythematosus associated to multiple myeloma. The cases are discussed in the light of a review of the literature. The clinical, laboratory and radiographic findings of the patients...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2008-07, Vol.26 (4), p.667-670
Main Authors: MAAMAR, M, TAZI MEZALEK, Z, HARMOUCHE, H, ADNAOUI, M, AOUNI, M, MAAOUNI, A
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Combined Chemotherapy Protocols
Biological and medical sciences
Cytarabine
Dexamethasone
Diseases of the osteoarticular system
Fatal Outcome
Female
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulinopathies
Immunopathology
Lupus Erythematosus, Systemic - complications
Medical sciences
Melphalan - therapeutic use
Middle Aged
Multiple Myeloma - complications
Multiple Myeloma - drug therapy
Prednisone - therapeutic use
Remission Induction
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Vincristine
Online Access:Get full text
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Summary:The association of systemic lupus erythematosus and multiple myeloma is uncommon. We report two cases of systemic lupus erythematosus associated to multiple myeloma. The cases are discussed in the light of a review of the literature. The clinical, laboratory and radiographic findings of the patients, as well as the subsequent therapeutic approach are discussed. A systematic review of all the other cases of this association is performed. We report two female patients of 50 and 35 years old who developed a multiple myeloma seven and three years respectively after the diagnosis of systemic lupus erythematosus. In the second case, systemic lupus erythematosus was associated to monoclonal gammopathy. One patient died after three months and one patient is still in remission after three years of the diagnosis of multiple myeloma. The coexistence of systemic lupus erythematosus and multiple myeloma is very rare and the possible pathogenetic mechanisms underlying this association remain unclear.
ISSN:0392-856X
1593-098X