Cocaine Metabolite Kinetics in the Newborn

The study goal was to determine the half-life elimination of cocaine and benzoylecgonine (BZE) in the newborn. Three 0.3-mL blood samples were collected during the first day of life. Urine was collected once daily. Cocaine and BZE concentrations were determined by gas chromatography-mass spectrometr...

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Bibliographic Details
Published in:Journal of analytical toxicology 1999-01, Vol.23 (1), p.24-28
Main Authors: Dempsey, Delia, Jacob, Peyton, Partridge, J. Colin, Jones, Reese T., Panganiban, Kristina, Rowbotham, Michael C.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chemistry Techniques, Analytical - methods
Cocaine - analogs & derivatives
Cocaine - blood
Cocaine - metabolism
Cocaine - pharmacokinetics
Cocaine - urine
Drug addictions
Female
Fetal Blood - chemistry
Gas Chromatography-Mass Spectrometry
Half-Life
Humans
Infant, Newborn
Medical sciences
Pregnancy
Toxicology
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Summary:The study goal was to determine the half-life elimination of cocaine and benzoylecgonine (BZE) in the newborn. Three 0.3-mL blood samples were collected during the first day of life. Urine was collected once daily. Cocaine and BZE concentrations were determined by gas chromatography-mass spectrometry. An extraction method was developed for measuring low concentrations of cocaine and BZE in small (0.1 mL) blood samples. Cocaine had a half-life of 11.6 h in one subject. The half-life of BZE during the first day of life, based on blood data in 13 subjects, was 16 h (95% confidence interval [CI], 12.8 to 21.4 h). The half-life of BZE during the first week of life, based on urine data in 16 subjects, was 11.2 h (95% CI, 10.1 to 11.8 h). The novel extraction method for small blood sample volumes should be applicable to other basic drugs.
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/23.1.24