Histone Octamer Transfer by a Chromatin-Remodeling Complex

RSC, an abundant, essential chromatin-remodeling complex related to SWI/SNF complex, catalyzes the transfer of a histone octamer from a nucleosome core particle to naked DNA. The newly formed octamer–DNA complex is identical with a nucleosome in all respects. The reaction requires ATP and involves a...

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Bibliographic Details
Published in:Cell 1999-02, Vol.96 (3), p.389-392
Main Authors: Lorch, Yahli, Zhang, Mincheng, Kornberg, Roger D
Format: Article
Language:English
Subjects:
Animals
Catalysis
Chromatin - chemistry
Chromatin - metabolism
DNA, Fungal - metabolism
DNA-Binding Proteins - chemistry
DNA-Binding Proteins - metabolism
Histones - chemistry
Histones - metabolism
Macromolecular Substances
Nucleosomes - chemistry
Nucleosomes - metabolism
Rats
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Transcription Factors - chemistry
Transcription Factors - metabolism
Xenopus laevis
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Summary:RSC, an abundant, essential chromatin-remodeling complex related to SWI/SNF complex, catalyzes the transfer of a histone octamer from a nucleosome core particle to naked DNA. The newly formed octamer–DNA complex is identical with a nucleosome in all respects. The reaction requires ATP and involves an activated RSC–nucleosome intermediate. The mechanism may entail formation of a duplex displacement loop on the nucleosome, facilitating the entry of exogeneous DNA and the release of the endogenous molecule.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(00)80551-6