An array of Pt-tip microelectrodes for extracellular monitoring of activity of brain slices

A microelectrode array (MEA) consisting of 34 silicon nitride passivated Pt-tip microelectrodes embedded on a perforated silicon substrate (porosity 35%) has been realized. The electrodes are 47 μm high, of which only the top 15 μm are exposed Pt-tips having a curvature of 0.5 μm. The MEA is intende...

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Bibliographic Details
Published in:Biosensors & bioelectronics 1999, Vol.14 (1), p.61-65
Main Authors: Thiébaud, Pierre, Beuret, Cynthia, Koudelka-Hep, Milena, Bove, Marco, Martinoia, Sergio, Grattarola, Massimo, Jahnsen, Henrik, Rebaudo, Renata, Balestrino, Maurizio, Zimmer, Jens, Dupont, Yves
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biosensors
Brain
Brain - physiology
Electric Impedance
Electrophysiology
extracellular recording
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
impedance
In Vitro Techniques
microelectrode arrays
Microelectrodes
Microscopy, Electron, Scanning
Passivation
Platinum
Pt-tip microelectrode
Silicon
Silicon nitride
Vertebrates: nervous system and sense organs
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Summary:A microelectrode array (MEA) consisting of 34 silicon nitride passivated Pt-tip microelectrodes embedded on a perforated silicon substrate (porosity 35%) has been realized. The electrodes are 47 μm high, of which only the top 15 μm are exposed Pt-tips having a curvature of 0.5 μm. The MEA is intended for extracellular recordings of brain slices in vitro. Here we report the fabrication, characterization and initial electrophysiological evaluation of the first generation of Pt-tip MEAs.
ISSN:0956-5663
1873-4235
DOI:10.1016/S0956-5663(98)00098-0