Alternative to endoscopic sinus surgery in the management of pediatric chronic rhinosinusitis refractory to oral antimicrobial therapy

• Published in: Otolaryngology-head and neck surgery 1999-02, Vol.120 (2), p.219-224
• Main Authors: BUCHMAN, CRAIG A., YELLON, ROBERT F., BLUESTONE, CHARLES D.
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - therapeutic use; Bacterial Infections - drug therapy; Bacterial Infections - microbiology; Child; Child, Preschool; Chronic Disease; Endoscopy; Female; Follow-Up Studies; Humans; Infant; Lactams; Male; Retrospective Studies; Rhinitis - microbiology; Rhinitis - therapy; Sinusitis - microbiology; Sinusitis - therapy; Therapeutic Irrigation - methods
• ISSN: 0194-5998; 1097-6817
• DOI: 10.1016/S0194-5998(99)70410-9

We determined the safety, feasibility, and efficacy of a treatment regimen consisting of maxillary sinus aspiration and irrigation with or without adenoidectomy, followed by culture-directed intravenous antibiotics and oral prophylaxis, for children with chronic rhinosinusitis refractory to oral antimicrobial therapy. Twenty-seven children (age 1–12 years, mean 6.7 years) with symptomatic (mean duration 16 months) and computed tomography-proven sinus disease, which persisted despite at least 1 month of oral antibiotics, were treated. Twenty-four patients (89%) had complete resolution of their presenting symptoms after intravenous therapy; in 3 (11%), intravenous therapy failed and endoscopic sinus surgery was required. Follow-up data were available for 26 of the children (96%); 23 of them had initial complete resolution. At last follow-up (mean 282 days, range 26–1095 days), 10 of these 23 patients (44%) remained asymptomatic, and 13 (57%) had had at least one other episode of sinusitis (mean 1.0, range 1–3) treated with oral antibiotics, with resolution. Treatment-related complications included superficial thrombophlebitis (7%), diarrhea (7%), intravenous catheter guide-wire kink requiring venotomy (4%), and serum sickness–like syndrome (4%). These preliminary results suggest that this treatment plan is relatively safe and feasible and that it may be a reasonable alternative to endoscopic sinus surgery in children with chronic rhinosinusitis unresponsive to orally administered antimicrobial therapy. (Otolaryngol Head Neck Surg 1999;120:219-24.)