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Polymorphic variability in the interleukin (IL)-1beta promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1beta production

Interleukin (IL)-1beta is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1beta polymorphic variability in conditioning the immunopathogenesis of severe malarial anemia (SMA) remains undefined, relationships between IL-1beta promoter...

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Bibliographic Details
Published in:The Journal of infectious diseases 2008-10, Vol.198 (8), p.1219-1226
Main Authors: Ouma, Collins, Davenport, Gregory C, Awandare, Gordon A, Keller, Christopher C, Were, Tom, Otieno, Michael F, Vulule, John M, Martinson, Jeremy, Ong'echa, John M, Ferrell, Robert E, Perkins, Douglas J
Format: Article
Language:English
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Summary:Interleukin (IL)-1beta is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1beta polymorphic variability in conditioning the immunopathogenesis of severe malarial anemia (SMA) remains undefined, relationships between IL-1beta promoter variants (-31C/T and -511A/G), SMA (hemoglobin [Hb] level
ISSN:0022-1899
DOI:10.1086/592055