Adipokines influencing metabolic and cardiovascular disease are differentially regulated in maintenance hemodialysis

• Published in: Metabolism, clinical and experimental clinical and experimental, 2008-10, Vol.57 (10), p.1414-1421
• Main Authors: Ziegelmeier, Michaela, Bachmann, Anette, Seeger, Jeannette, Lossner, Ulrike, Kratzsch, Jürgen, Blüher, Matthias, Stumvoll, Michael, Fasshauer, Mathias
• Format: Article
• Language: English
• Subjects: Adipokines - blood; Adult; Aged; Aged, 80 and over; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood Glucose - metabolism; Case-Control Studies; Diabetes Mellitus, Type 2 - blood; Emergency and intensive care: renal failure. Dialysis management; Endocrinology & Metabolism; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Glomerular Filtration Rate; Humans; Insulin - blood; Insulin Resistance; Intensive care medicine; Interleukin-6 - blood; Kidney Diseases - blood; Kidney Diseases - therapy; Lipid Metabolism; Male; Medical sciences; Middle Aged; Multivariate Analysis; Renal Dialysis; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0026-0495; 1532-8600
• DOI: 10.1016/j.metabol.2008.05.011

Abstract Adipokines including leptin, adiponectin, visfatin, resistin, and interleukin (IL)-6 significantly influence energy metabolism, insulin sensitivity, and cardiovascular health. In the current study, we investigated serum levels of these adipokines in diabetic and nondiabetic patients on maintenance hemodialysis (MD) as compared with controls with a glomerular filtration rate greater than 50 mL/min. Serum leptin, adiponectin, high–molecular-weight (HMW) adiponectin, visfatin, resistin, and IL-6 were determined by enzyme-linked immunosorbent assay in control (n = 60) and MD (n = 60) patients and correlated to clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation. Adiponectin, visfatin, resistin, and IL-6 were significantly elevated in MD patients as compared with controls. In multivariate analyses, sex and body mass index were independently correlated with serum leptin levels in both controls and MD patients. Furthermore, insulin resistance was independently and negatively associated with adiponectin and HMW adiponectin in both groups. Moreover, circulating resistin levels were independently correlated with serum visfatin concentrations in control and MD patients. However, various independent associations were only found in either controls or patients on MD. Thus, serum IL-6 levels were strongly and independently associated with C reactive protein and resistin in MD patients but not control subjects. We show that levels of various adipokines are significantly increased in MD patients. Furthermore, regulation of adipokines in vivo strongly depends on renal function. Regulation of HMW adiponectin is similar as compared with total adiponectin in the patients studied.