The Anatomic Site of Photodynamic Therapy is a Determinant for Immunosuppression in a Murine Model

— The role of the irradiation site in the induction of suppression of the contact hypersensitivity (CHS) response following photodynamic therapy (PDT) was examined in a murine model. Laser irradiation on the flanks of nontumor‐bearing Photofrin®‐injected mice caused suppression of the CHS response....

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Bibliographic Details
Published in:Photochemistry and photobiology 1999-02, Vol.69 (2), p.222-225
Main Authors: Musser, David A., Camacho, Susan H., Manderscheid, Patricia A., Oseroff, Allan R.
Format: Article
Language:English
Subjects:
Animals
Dermatitis, Contact - immunology
Dermatitis, Contact - prevention & control
Dihematoporphyrin Ether - therapeutic use
Female
Immunosuppression - methods
Lasers
Mice
Mice, Inbred BALB C
Neoplasm Transplantation
Photochemotherapy - methods
Thigh
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Summary:— The role of the irradiation site in the induction of suppression of the contact hypersensitivity (CHS) response following photodynamic therapy (PDT) was examined in a murine model. Laser irradiation on the flanks of nontumor‐bearing Photofrin®‐injected mice caused suppression of the CHS response. If the irradiation was conducted on a subcutaneously implanted foil disc on the flank no immunosuppression occurred, indicating that no suppressive factor (s) of sufficient quantity to cause suppression was released from the skin, but rather irradiation of internal organs was the cause. Irradiation of tumors implanted on the flanks of mice reduced the suppression, suggesting an immunopotentiating effect of PDT. Irradiation on the thigh in the presence or absence of a tumor gave no immunosuppression. These results suggest that the anatomic site of irradiation is one determinant for the elicitation of suppression of the CHS response.
ISSN:0031-8655
1751-1097
DOI:10.1111/j.1751-1097.1999.tb03277.x