Optimization of the Mechanical Properties and Water-Vapor Transmission Properties of Free Films of Hydroxypropylmethylcellulose

Free films of hydroxypropylmethylcellulose were prepared by a spraying technique. Methocel E5 and Methocel E15 were used in varying proportions in the preparation of films. The free films were studied for their mechanical properties and moisture permeability characteristics. A 22 factorial design wa...

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Bibliographic Details
Published in:Drug development and industrial pharmacy 1999, Vol.25 (1), p.95-98
Main Authors: Nagarsenker, M. S., Hegde, D. D.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chemistry, Pharmaceutical
General pharmacology
Hypromellose Derivatives
Medical sciences
Methylcellulose - analogs & derivatives
Methylcellulose - chemistry
Permeability
Pharmaceutic Aids - chemistry
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Solubility
Stress, Mechanical
Tensile Strength
Water
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Summary:Free films of hydroxypropylmethylcellulose were prepared by a spraying technique. Methocel E5 and Methocel E15 were used in varying proportions in the preparation of films. The free films were studied for their mechanical properties and moisture permeability characteristics. A 22 factorial design was used to quantitate the effect of each polymer on the tensile strength and permeability constant of the films.
ISSN:0363-9045
1520-5762
DOI:10.1081/DDC-100102147