Decreased GAP-43/B-50 phosphorylation in striatal synaptic plasma membranes after circling motor behavior during development

We evaluated the in vitro phosphorylation of the presynaptic substrate of protein kinase C (PKC), GAP-43/B-50 and the PKC activity in the striatum of rats submitted to a circling training (CT) test during postnatal development. Motor activity at 30 days of age, but not at other ages, produced a unil...

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Bibliographic Details
Published in:Brain research. Molecular brain research. 1999-02, Vol.65 (1), p.34-43
Main Authors: Paratcha, Gustavo Ch, Ibarra, Gustavo R, Wolansky, Marcelo J, Rodriguez, Jorge A, Azcurra, Julio M
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal - physiology
Biological and medical sciences
Blotting, Western
Cell Membrane - metabolism
Circling training
Conditioning (Psychology) - physiology
Corpus Striatum - growth & development
Corpus Striatum - metabolism
Development
Development. Senescence. Regeneration. Transplantation
Fundamental and applied biological sciences. Psychology
GAP-43 Protein - analysis
GAP-43 Protein - metabolism
GAP-43/B-50
Locomotion - physiology
Male
Motor Neurons - enzymology
Phosphorylation
PKC
Protein Kinase C - metabolism
Rat striatum
Rats
Rats, Sprague-Dawley
SPM
Synapses - enzymology
Vertebrates: nervous system and sense organs
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Summary:We evaluated the in vitro phosphorylation of the presynaptic substrate of protein kinase C (PKC), GAP-43/B-50 and the PKC activity in the striatum of rats submitted to a circling training (CT) test during postnatal development. Motor activity at 30 days of age, but not at other ages, produced a unilateral reduction (−29.5%; p
ISSN:0169-328X
1872-6941
DOI:10.1016/S0169-328X(98)00327-1