Involvement of ERK and AKT signaling in the growth effect of arginine vasopressin on adult rat cardiac fibroblast and the modulation by simvastatin

• Published in: Molecular and cellular biochemistry 2008-10, Vol.317 (1-2), p.33-41
• Main Authors: He, Yan-Ping, Zhao, Lian-You, Zheng, Qiang-Sun, Liu, Shao-Wei, Zhao, Xiao-Yan, Lu, Xiao-Long, Niu, Xiao-Lin, Li, Xia
• Format: Article
• Language: English
• Subjects: Animals; Arginine Vasopressin - pharmacology; Biochemistry; Biomedical and Life Sciences; Cardiology; Cell Proliferation - drug effects; Deoxyribonucleic acid; DNA; DNA - biosynthesis; Enzyme Activation - drug effects; Enzymes; Extracellular Signal-Regulated MAP Kinases - metabolism; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - enzymology; Kinases; Life Sciences; Male; Medical Biochemistry; Mevalonic Acid - pharmacology; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - metabolism; Molecular biology; Myocardium - cytology; Oncology; Phosphatidylinositol 3-Kinases - metabolism; Protein Kinase C - metabolism; Proteins; Proto-Oncogene Proteins c-akt - metabolism; Rats; Rats, Sprague-Dawley; Rodents; Signal Transduction - drug effects; Simvastatin - pharmacology; Statins
• ISSN: 0300-8177; 1573-4919
• DOI: 10.1007/s11010-008-9802-9

Arginine vasopressin (AVP) has been shown to directly induce neonatal rat cardiac fibroblasts (CFs) proliferation, a major component involved in cardiac hypertrophy. Herein, we explored whether AVP is also a growth factor for adult rat CFs and, if so, whether the growth effect could be inhibited by simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. AVP significantly increased DNA synthesis in adult rat CFs by 73.5 ± 5.1% (P