Expression of uncoupling protein-3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle

We sought a correlation between rat skeletal muscle triiodothyronine (T3)-mediated regulation of uncoupling protein-3 (UCP3) expression and mitochondrial activity. UCP3 mRNA expression increased strongly during the hypothyroid-hyperthyroid transition. The rank order of mitochondrial State 3 and Stat...

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Bibliographic Details
Published in:FEBS letters 1999-02, Vol.444 (2), p.250-254
Main Authors: Lanni, A, Beneduce, L, Lombardi, A, Moreno, M, Boss, O, Muzzin, P, Giacobino, J.P, Goglia, F
Format: Article
Language:English
Subjects:
Animals
Carrier Proteins - genetics
Energy Metabolism - drug effects
Gene Expression Regulation - genetics
Hyperthyroidism - metabolism
Hypothyroidism - metabolism
Ion Channels
IOP, iopanoic acid
Kinetics
Male
Membrane potential
Mitochondria, Muscle - metabolism
Mitochondrial Proteins
Mitochondrion
Muscle, Skeletal - metabolism
Oxygen Consumption
Protons
PTU, 6-n-propylthiouracil
Rats
Rats, Wistar
RCR, respiratory control ratio
RNA, Messenger - metabolism
Skeletal muscle
State 3, respiratory state in which ATP synthesis is at maximal rate
State 4, respiratory state in which there is no ATP synthesis
T3, triiodothyronine
Thyroid hormone
Triiodothyronine - pharmacology
UCP1, uncoupling protein-1
UCP2, uncoupling protein-2
UCP3, uncoupling protein-3
Uncoupling protein
Uncoupling Protein 3
ΔΨ, mitochondrial transmembrane electric potential difference
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Summary:We sought a correlation between rat skeletal muscle triiodothyronine (T3)-mediated regulation of uncoupling protein-3 (UCP3) expression and mitochondrial activity. UCP3 mRNA expression increased strongly during the hypothyroid-hyperthyroid transition. The rank order of mitochondrial State 3 and State 4 respiration rates was hypothyroid
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(99)00061-7