Different narrowband UVB dosage regimens in dark skinned psoriatics: a preliminary study

Background: Psoriasis is a common and relapsing disease, which is both physically and psychologically disabling. Narrowband UVB (NB‐UVB) is used in fair‐skinned population in suberythemogenic doses with good results; however, in the darker skin population (skin types III, IV, V) erythemogenic doses...

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Published in:Photodermatology, photoimmunology & photomedicine photoimmunology & photomedicine, 2008-10, Vol.24 (5), p.256-259
Main Authors: Youssef, Randa M., Mahgoub, Doaa, Mashaly, Heba M., El-Nabarawy, Eman, Samir, Nesreen, El-Mofty, Medhat
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Chronic Disease
Dermatology
Female
Humans
Male
MED
Medical sciences
Middle Aged
NB-UVB
psoriasis
Psoriasis - therapy
Psoriasis. Parapsoriasis. Lichen
Skin Pigmentation
suberythemogenic dose
Ultraviolet Rays
Ultraviolet Therapy - methods
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Summary:Background: Psoriasis is a common and relapsing disease, which is both physically and psychologically disabling. Narrowband UVB (NB‐UVB) is used in fair‐skinned population in suberythemogenic doses with good results; however, in the darker skin population (skin types III, IV, V) erythemogenic doses have not been thoroughly investigated. Aim: A left–right bilateral comparative trial was carried out to compare the suberythemogenic dose of NB‐UVB vs. erythemogenic dose in the treatment of dark‐skinned psoriatic patients. Patients and methods: The study was conducted on 20 patients with chronic plaque psoriasis. The left side was treated with the dose causing minimal erythema [100% of minimal erythema dose (MED)] while the right side received 70% of this MED (suberythemogenic side). Results: Our results revealed no statistically significant difference in PASI final and in the percentage of reduction of PASI score between both sides as well as the total number of sessions (P‐value>0.05), while the total cumulative UVB dose on the suberythemogenic side was significantly lower (P‐value
ISSN:0905-4383
1600-0781
DOI:10.1111/j.1600-0781.2008.00371.x