Relationship between clinical course and Diffusion-weighted MRI findings in sporadic Creutzfeldt-Jakob Disease

The aim of this study was to investigate the relationship between clinical course and diffusion-weighted MRI (DWI) findings in sporadic Creutzfeldt-Jakob Disease (sCJD). We reviewed clinical records and MRI examination in nine probable sCJD. According to hyperintense signal distribution on DWI, the...

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Bibliographic Details
Published in:Neurological sciences 2008-09, Vol.29 (4), p.251-255
Main Authors: Yi, Sang-Hun, Park, Key-Chung, Yoon, Sung-Sang, Kim, Eui-Jong, Shin, Won-Chul
Format: Article
Language:English
Subjects:
Aged
Akinetic Mutism - pathology
Akinetic Mutism - physiopathology
Aphasia - pathology
Aphasia - physiopathology
Basal Ganglia - pathology
Basal Ganglia - physiopathology
Cerebral Cortex - pathology
Cerebral Cortex - physiopathology
Creutzfeldt-Jakob Syndrome - classification
Creutzfeldt-Jakob Syndrome - diagnosis
Creutzfeldt-Jakob Syndrome - physiopathology
Diffusion Magnetic Resonance Imaging - methods
Disease Progression
Female
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Nerve Fibers, Myelinated - pathology
Neurologic Examination
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Original Article
Predictive Value of Tests
Prognosis
Psychiatry
Quadriplegia - pathology
Quadriplegia - physiopathology
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Summary:The aim of this study was to investigate the relationship between clinical course and diffusion-weighted MRI (DWI) findings in sporadic Creutzfeldt-Jakob Disease (sCJD). We reviewed clinical records and MRI examination in nine probable sCJD. According to hyperintense signal distribution on DWI, the patients were classified into two groups with cortical ribbon plus basal ganglia hyperintensity (6/9) and with only increased cortical signals (3/9). Clinical features including quadriparesis (3/6), akinetic mutism (2/6), and dysphasia (2/6), which were usually observed in the more advanced stage of CJD, were noted only in patients with cortical ribbon plus basal ganglia hyperintensity at the time of initial DWI examination. The patients with the cortical plus basal ganglia hyperintensity (6.4±1.7 weeks) had a shorter interval from symptom onset to akinetic mutism than those with only cortical ribbon hyperintensity (26.0±22.5 weeks) ( p =0.02). These findings suggest that DWI may predict the clinical course of CJD.
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-008-0976-4