C-reactive protein and aetiological subtypes of cerebral infarction

Objective We have sought to relate C-reactive protein (CRP), a peripheral marker of inflammation frequently elevated in stroke patients, with aetiology and prognosis of acute cerebral infarction. Patients and methods Patients were included after a first-ever CT/MR documented cerebral infarction. CRP...

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Bibliographic Details
Published in:Neurological sciences 2008-09, Vol.29 (4), p.245-249
Main Authors: Terruzzi, Alessandro, Valente, Laura, Mariani, Roberto, Moschini, Luca, Camerlingo, Massimo
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Aged
Aged, 80 and over
Biomarkers - analysis
Biomarkers - blood
C-Reactive Protein - analysis
C-Reactive Protein - metabolism
Cerebral Infarction - blood
Cerebral Infarction - diagnosis
Cerebral Infarction - etiology
Early Diagnosis
Female
Humans
Inflammation - blood
Inflammation - complications
Inflammation - diagnosis
Intracranial Embolism - blood
Intracranial Embolism - diagnosis
Male
Medicine
Medicine & Public Health
Middle Aged
Mortality
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Original Article
Predictive Value of Tests
Prognosis
Psychiatry
Time Factors
Up-Regulation - physiology
Young Adult
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Summary:Objective We have sought to relate C-reactive protein (CRP), a peripheral marker of inflammation frequently elevated in stroke patients, with aetiology and prognosis of acute cerebral infarction. Patients and methods Patients were included after a first-ever CT/MR documented cerebral infarction. CRP was measured from blood samples taken within the 6th hour of the onset. Titres of C-reactive protein were stratified in quartiles. Aetiology of stroke was from TOAST criteria. Prognosis was mortality within 14 days of stroke. Results The study included 648 stroke patients. They were 335 women and 313 men, with a mean age of 70.3 years (median 72). CRP quartiles were mostly increased in cardioembolic strokes, After logistic regression analysis CRP remained an independent factor of 14-day mortality. Conclusions Our study suggests that in the acute phase of the cerebral infarction CRP might be either a marker of cardioembolism or a predictive factor for short-term mortality.
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-008-0975-5