Current strategies in the search for novel antiparasitic agents

The market for antiparasitic products comprises the largest segment for sales of livestock and companion-animal healtheare agents. Despite the availability of highly effective, broad-spectrum agents, there remains a need for safer, more convenient and more environmentally friendly products that will...

Full description

Saved in:
Bibliographic Details
Published in:International journal for parasitology 1999, Vol.29 (1), p.95-103
Main Author: Witty, Michael J.
Format: Article
Language:English
Subjects:
Animals
Animals, Domestic - parasitology
Anthelmintics - chemistry
Anthelmintics - pharmacology
Anthelmintics - therapeutic use
Antiparasitic Agents - chemistry
Antiparasitic Agents - pharmacology
Antiparasitic Agents - therapeutic use
Automation mechanism
Drug discovery
Drug Evaluation, Preclinical
Helminthiasis, Animal - drug therapy
Helminthiasis, Animal - prevention & control
Helminths - drug effects
Intestinal Diseases, Parasitic - drug therapy
Intestinal Diseases, Parasitic - prevention & control
Intestinal Diseases, Parasitic - veterinary
Market
Parasites - drug effects
Parasitic Diseases, Animal - drug therapy
Parasitic Diseases, Animal - prevention & control
Screen
Source library
Target compound
Veterinary Drugs - chemistry
Veterinary Drugs - pharmacology
Veterinary Drugs - therapeutic use
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The market for antiparasitic products comprises the largest segment for sales of livestock and companion-animal healtheare agents. Despite the availability of highly effective, broad-spectrum agents, there remains a need for safer, more convenient and more environmentally friendly products that will overcome the ever-present threat of resistance development. The very high cost of discovering and developing a new drug, especially for use in livestock, is reflected in the limited number of new classes of antiparasitic agent launched on the market. New strategies are being adopted to minimise the cost of discovering potential drug candidates by maximising the chance of identifying a useful target mechanism of action and by speeding the time to discover and optimise a lead structure. These rely heavily on new technologies in target identification, screen development and lead optimisation. Examples of these will be discussed and speculation made about the possible factors that could influence the future shape of antiparasitic control.
ISSN:0020-7519
1879-0135
DOI:10.1016/S0020-7519(98)00193-3