The porcine hormone-sensitive lipase gene: sequence, structure, polymorphisms and linkage mapping

The porcine hormone‐sensitive lipase gene and its cDNA have been isolated and sequenced. Several putative regulatory sequences have been detected in the promotor region. The deduced amino acid sequence is 85% identical to the corresponding human, mouse and rat sequence. A search for polymorphisms re...

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Bibliographic Details
Published in:Animal genetics 1999-02, Vol.30 (1), p.10-16
Main Authors: Harbitz, 1I., Langset, M., Ege, A. G., Høyheim, B., Davies, W.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Biological and medical sciences
Chromosome Mapping - veterinary
DNA, Complementary - chemistry
DNA, Complementary - isolation & purification
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Enzymologic
Gene Library
gene sequence
Genes. Genome
Genetic Variation
hormone-sensitive lipase
Humans
Introns
Mice
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
pig
polymorphism
Polymorphism, Genetic
Rats
Restriction Mapping - veterinary
Sequence Alignment - veterinary
Sterol Esterase - genetics
Swine
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Summary:The porcine hormone‐sensitive lipase gene and its cDNA have been isolated and sequenced. Several putative regulatory sequences have been detected in the promotor region. The deduced amino acid sequence is 85% identical to the corresponding human, mouse and rat sequence. A search for polymorphisms revealed one intronic and one exonic polymorphism, the latter resulting in a conservative amino acid substitution. Linkage mapping located the LIPE gene close to the calcium release channel (CRC) locus on chromosome 6.
ISSN:0268-9146
1365-2052
DOI:10.1046/j.1365-2052.1999.00412.x