Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction

Coronary artery disease (CAD) and myocardial infarction (MI) have a genetic basis, but the precise genetic underpinning remains controversial. Recently, an association of the LRP8 R952Q polymorphism (rs5174) with familial premature CAD/MI was reported. We analysed rs5174 (or the perfect proxy rs5177...

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Bibliographic Details
Published in:Journal of molecular medicine (Berlin, Germany) Germany), 2008-10, Vol.86 (10), p.1163-1170
Main Authors: Lieb, Wolfgang, Zeller, Tanja, Mangino, Massimo, Götz, Anika, Braund, Peter, Wenzel, Juergen J., Horn, Christian, Proust, Carole, Linsel-Nitschke, Patrick, Amouyel, Philippe, Bruse, Petra, Arveiler, Dominique, König, Inke R., Ferrières, Jean, Ziegler, Andreas, Balmforth, Anthony J., Evans, Alun, Ducimetière, Pierre, Cambien, Francois, Hengstenberg, Christian, Stark, Klaus, Hall, Alistair S., Schunkert, Heribert, Blankenberg, Stefan, Samani, Nilesh J., Erdmann, Jeanette, Tiret, Laurence
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cardiology. Vascular system
Coronary Artery Disease - genetics
Coronary heart disease
Family Health
Female
Gene Frequency
General aspects
Genetic Predisposition to Disease - genetics
Genotype
Germany
Heart
Human Genetics
Humans
Internal Medicine
LDL-Receptor Related Proteins
Male
Medical sciences
Middle Aged
Molecular Medicine
Myocardial Infarction - genetics
Original Article
Polymorphism, Single Nucleotide
Receptors, Lipoprotein - genetics
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Summary:Coronary artery disease (CAD) and myocardial infarction (MI) have a genetic basis, but the precise genetic underpinning remains controversial. Recently, an association of the LRP8 R952Q polymorphism (rs5174) with familial premature CAD/MI was reported. We analysed rs5174 (or the perfect proxy rs5177) in 1,210 patients with familial MI and 1,015 controls from the German MI Family study, in 1,926 familial CAD (1,377 with MI) patients and 2,938 controls from the Wellcome Trust Case Control Consortium (WTCCC) MI/CAD cohort, in 346 CAD patients and 351 controls from the AtheroGene study and in 295 men with incident CAD and 301 controls from the Prospective Epidemiological Study of MI study and found no evidence for association in any of the populations studied. In the WTCCC and the German MI Family studies, additional single-nucleotide polymorphisms in the LRP8 gene were analysed and displayed no evidence for association either.
ISSN:0946-2716
1432-1440
DOI:10.1007/s00109-008-0376-5