Diversity-oriented synthesis of novel polycyclic scaffolds using polymer-bound reagents

A concise sequence utilizing a Petasis three component reaction followed by a tandem aza-Cope-Mannich cyclization afforded novel polycyclic heterocycles in good yield; alternative iminium cyclization based on a Pictet-Spengler reaction or aminal formation led to divergent pathways affording skeletal...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2008-01 (38), p.4619-4621
Main Authors: García-Cuadrado, Domingo, Barluenga, Sofia, Winssinger, Nicolas
Format: Article
Language:English
Subjects:
Aza Compounds - chemistry
Cyclization
Heterocyclic Compounds - chemical synthesis
Indicators and Reagents - chemistry
Mannich Bases - chemistry
Polycyclic Compounds - chemical synthesis
Polymers - chemistry
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Summary:A concise sequence utilizing a Petasis three component reaction followed by a tandem aza-Cope-Mannich cyclization afforded novel polycyclic heterocycles in good yield; alternative iminium cyclization based on a Pictet-Spengler reaction or aminal formation led to divergent pathways affording skeletal diversity.
ISSN:1359-7345
1364-548X
DOI:10.1039/b807869f