Gliclazide

The crystal structure of gliclazide, N-[(perhydrocyclopenta [c]pyrrol-2-yl)aminocarbonyl]-p-toluenesulfonamide, C15H21B3O3S, a second-generation oral hypoglycemic agent, contains discrete molecules with normal molecular dimensions. Both of the five-membered fused rings adopt envelope conformations....

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Bibliographic Details
Published in:Acta crystallographica. Section C, Crystal structure communications Crystal structure communications, 1999-01, Vol.55 (1), p.74-75
Main Authors: Parvez, M., Arayne, M. S., Zaman, M. K., Sultana, N.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Condensed matter: structure, mechanical and thermal properties
Crystallography, X-Ray
Exact sciences and technology
General and cellular metabolism. Vitamins
Gliclazide - chemistry
Heterocyclic compounds
Hypoglycemic Agents - chemistry
Medical sciences
Molecular Structure
Organic compounds
Pharmacology. Drug treatments
Physics
Structure of solids and liquids
crystallography
Structure of specific crystalline solids
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Summary:The crystal structure of gliclazide, N-[(perhydrocyclopenta [c]pyrrol-2-yl)aminocarbonyl]-p-toluenesulfonamide, C15H21B3O3S, a second-generation oral hypoglycemic agent, contains discrete molecules with normal molecular dimensions. Both of the five-membered fused rings adopt envelope conformations. The molecules are linked into chains by intermolecular hydrogen bonds involving amino-H atoms, with N...O separations of 2.967 (3) and 2.949 (3) A.
ISSN:0108-2701
1600-5759
DOI:10.1107/S0108270198009883