Protective effects of some flavonoids on the renal cellular membrane

By assaying lactate dehydrogenase and malondialdehyde leakage from LLC-PK 1 cells in culture, a study was conducted to clarify whether flavonoid compounds ameliorate renal cellular injury. The cells were cultured with various concentrations of samples under routine conditions. The results demonstrat...

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Bibliographic Details
Published in:Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1999, Vol.51 (1), p.9-14
Main Authors: Yokozawa, Takako, Dong, Erbo, Kawai, Yoshiko, Gemba, Munekazu, Shimizu, Mineo
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Membrane - drug effects
Cell Survival - drug effects
Cells, Cultured
Flavone
Flavonoids - chemistry
Flavonoids - pharmacology
Flavonol
Kidney, cellular membrane
L-Lactate Dehydrogenase - metabolism
Lactate dehydrogenase
LLC-PK 1
LLC-PK1 Cells - drug effects
LLC-PK1 Cells - metabolism
Malondialdehyde
Malondialdehyde - metabolism
Medical sciences
Membrane, renal cellular
Pharmacology. Drug treatments
Renal cellular membrane
Structure-Activity Relationship
Swine
Urinary system
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Summary:By assaying lactate dehydrogenase and malondialdehyde leakage from LLC-PK 1 cells in culture, a study was conducted to clarify whether flavonoid compounds ameliorate renal cellular injury. The cells were cultured with various concentrations of samples under routine conditions. The results demonstrated that baicalin, cirsimaritin, 6-hydroxy-luteolin, luteolin, plantaginin, rhoifolin, sorbarin, afzelin, hyperin, isoquercitrin, isorhamnetin, kaempferitrin, kaempferol-7-glucoside, oxyayanin A, quercetin, quercitrin, rhamnetin and rutin exerted marked protective effects on the cells, whereas acacetin, apigenin, apiin, cirsilineol, genkwanin, pectolinarin and tetramethylquercitin had virtually no effect. In the light of these findings, we propose that the general capability of these compounds is largely decided by the number and position of phenolic hydroxyl groups linked to the structural backbone.
ISSN:0940-2993
1618-1433
DOI:10.1016/S0940-2993(99)80050-5