Alteration of ghrelin-neuropeptide Y network in obese patients with polycystic ovary syndrome: role of hyperinsulinism

Summary Objective  Insulin, ghrelin, neuropeptide Y (NPY) and leptin interact in the regulation of energy homeostasis. Most of these signals are altered in polycystic ovary syndrome (PCOS), which is characterized by a high prevalence of obesity. The present study was conducted to evaluate ghrelin–NP...

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Published in:Clinical endocrinology (Oxford) 2008-10, Vol.69 (4), p.562-567
Main Authors: Romualdi, Daniela, De Marinis, Laura, Campagna, Giuseppe, Proto, Caterina, Lanzone, Antonio, Guido, Maurizio
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Ghrelin - blood
Ghrelin - metabolism
Ghrelin - pharmacology
Glucose Tolerance Test
Humans
Hyperinsulinism - blood
Hyperinsulinism - complications
Hyperinsulinism - metabolism
Hypoglycemic Agents - therapeutic use
Insulin - blood
Insulin - metabolism
Leptin - blood
Leptin - metabolism
Medical sciences
Metabolic diseases
Metformin - therapeutic use
Neuropeptide Y - blood
Neuropeptide Y - metabolism
Obesity
Obesity - blood
Obesity - complications
Obesity - drug therapy
Obesity - metabolism
Pilot Projects
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - drug therapy
Polycystic Ovary Syndrome - metabolism
Signal Transduction - drug effects
Signal Transduction - physiology
Vertebrates: endocrinology
Young Adult
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Summary:Summary Objective  Insulin, ghrelin, neuropeptide Y (NPY) and leptin interact in the regulation of energy homeostasis. Most of these signals are altered in polycystic ovary syndrome (PCOS), which is characterized by a high prevalence of obesity. The present study was conducted to evaluate ghrelin–NPY and ghrelin–leptin interplays in relation to insulin secretion in obese PCOS subjects. Design  Pilot prospective study. Patients  Seven obese PCOS women and seven age–weight matched controls. Measurements  Hormonal measurements, oral glucose tolerance test (OGTT) and a ghrelin test (1 µg/kg i.v. bolus). PCOS patients repeated the clinical work‐up after 4 months of metformin treatment (1500 mg/day orally). Results  At baseline, PCOS women showed a significantly higher insulinaemic response to the OGTT compared to controls (P 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2008.03204.x