Juvenile Chronic Myelogenous Leukemia, Neurofibromatosis 1, and Xanthoma

The triple association of leukemia, xanthomatous skin lesions, and neurofibromatosis 1 (NF) was first described by Royer et al. in 1958. Most of the leukemias were of the juvenile chronic myelogenous type (JCML). We describe a 7‐year‐old male child with xanthoma, neurofibromatosis 1, and juvenile ch...

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Bibliographic Details
Published in:Journal of dermatology 1999-01, Vol.26 (1), p.33-35
Main Authors: Jang, Kyoung‐Ae, Choi, Jee‐Ho, Sung, Kyung‐Jeh, Moon, Kee‐Chan, Koh, Jai‐Kyoung, Im, Dong‐Jin
Format: Article
Language:English
Subjects:
Bone Marrow - pathology
Child
Humans
juvenile chronic myelogenous leukemia (JCML)
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - complications
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology
Male
neurofibromatosis 1 (NF1)
Neurofibromatosis 1 - complications
Neurofibromatosis 1 - pathology
Skin - pathology
Skin Diseases - complications
Skin Diseases - pathology
xanthoma
Xanthomatosis - complications
Xanthomatosis - pathology
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Summary:The triple association of leukemia, xanthomatous skin lesions, and neurofibromatosis 1 (NF) was first described by Royer et al. in 1958. Most of the leukemias were of the juvenile chronic myelogenous type (JCML). We describe a 7‐year‐old male child with xanthoma, neurofibromatosis 1, and juvenile chronic myelogenous leukemia. His mother also had NF1. We suggest that the presence of xanthomas and NF1 in a young child should raise awareness of the possible development of JCML, especially in patients with a family history of NF1.
ISSN:0385-2407
1346-8138
DOI:10.1111/j.1346-8138.1999.tb03506.x