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Isolated polycystic liver disease not linked to polycystic kidney disease 1 and 2

Autosomal dominant polycystic liver disease occurs commonly in association with autosomal dominant polycystic kidney disease, types 1 and 2. It may also exist as a separate entity, genetically distinct from autosomal dominant polycystic kidney disease types 1 and 2, as has been recently established...

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Bibliographic Details
Published in:Digestive diseases and sciences 1999-02, Vol.44 (2), p.385-388
Main Authors: IGLESIAS, D. M, PALMITANO, J. A, ARRIZURIETA, E, KORNBLIHTT, A. R, HERRERA, M, BERNATH, V, MARTIN, R. S
Format: Article
Language:English
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Summary:Autosomal dominant polycystic liver disease occurs commonly in association with autosomal dominant polycystic kidney disease, types 1 and 2. It may also exist as a separate entity, genetically distinct from autosomal dominant polycystic kidney disease types 1 and 2, as has been recently established to exist in a Belgian family. We report here a large Argentinian family of Spanish-Belgian ancestry with autosomal dominant polycystic liver disease, where proximal and distal markers for both polycystic kidney disease 1 and 2 failed to demonstrate genetic linkage. The data support the notion that polycystic liver disease and autosomal dominant polycystic kidney disease may have separate chromosomal loci.
ISSN:0163-2116
1573-2568
DOI:10.1023/A:1026623005401