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The Erythrocyte Sedimentation Rate Is Associated with the Development of Visual Complications in Biopsy-Proven Giant Cell Arteritis
Objectives To investigate the potential association between levels of the erythrocyte sedimentation rate (ESR) and specific clinical features of giant cell arteritis (GCA), in particular, visual loss, in a series of consecutive patients diagnosed with GCA at the reference hospital for a well-defined...
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| Published in: | Seminars in arthritis and rheumatism 2008-10, Vol.38 (2), p.116-123 |
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| creator | Lopez-Diaz, Maria J., MD Llorca, Javier, MD, PhD Gonzalez-Juanatey, Carlos, MD, PhD Peña-Sagredo, Jose L., MD, PhD Martin, Javier, MD, PhD Gonzalez-Gay, Miguel A., MD, PhD |
| description | Objectives To investigate the potential association between levels of the erythrocyte sedimentation rate (ESR) and specific clinical features of giant cell arteritis (GCA), in particular, visual loss, in a series of consecutive patients diagnosed with GCA at the reference hospital for a well-defined population. Methods The case records of all biopsy-proven GCA patients diagnosed at the Department of Medicine of Hospital Xeral-Calde (Lugo, Northwest Spain) between 1981 and 2006 were reviewed. Clinical information and laboratory data including ESR at the time of disease diagnosis were assessed. Results Only 10 (3.6%) of the 273 patients had ESR |
| doi_str_mv | 10.1016/j.semarthrit.2007.10.014 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69603695</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0049017207001850</els_id><sourcerecordid>69603695</sourcerecordid><originalsourceid>FETCH-LOGICAL-c457t-46cda9a6375bb7fbec074dc4d8a51046dd2d6c841db1d9ebb830ce4a5a1702103</originalsourceid><addsrcrecordid>eNqNkkGP0zAQhSMEYrsLfwH5AreUsZM4yQWpW5ZlpZVA7IK4WY49VV3SuHjcopz3j-PQipU4cbI8_t549N5kGeMw58Dl282ccKtDXAcX5wKgTuU58PJJNuNVIfJGyu9PsxlA2ebAa3GWnRNtADiXUD_PzngjBG-bcpY93K-RXYUxtfJmjMju0LotDlFH5wf2RafSDbEFkTcuXSz75eKaxaR6jwfs_W6CmV-xb472umdLv931zvyRE3MDu3R-R2P-OfgDDuza6YQvse_ZIkRM8zt6kT1b6Z7w5em8yL5-uLpffsxvP13fLBe3uSmrOualNFa3WhZ11XX1qkMDdWlNaRtdcSiltcJK05Tcdty22HVNAQZLXWleg-BQXGRvjn13wf_cI0W1dWTSKHpAvyclWwmFbKsENkfQBE8UcKV2wSW_R8VBTQGojXoMQE0BTC8pgCR9dfpj323RPgpPjifg9QnQZHS_Cnowjv5yAuqKCyESd3nkMDlycBgUGYeDSfEENFFZ7_5nmnf_NDG9G1I6_Q8ckTZ-H4bkuOKKhAJ1Ny3MtC9Qp11pKih-AzbmwQE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69603695</pqid></control><display><type>article</type><title>The Erythrocyte Sedimentation Rate Is Associated with the Development of Visual Complications in Biopsy-Proven Giant Cell Arteritis</title><source>ScienceDirect Journals</source><creator>Lopez-Diaz, Maria J., MD ; Llorca, Javier, MD, PhD ; Gonzalez-Juanatey, Carlos, MD, PhD ; Peña-Sagredo, Jose L., MD, PhD ; Martin, Javier, MD, PhD ; Gonzalez-Gay, Miguel A., MD, PhD</creator><creatorcontrib>Lopez-Diaz, Maria J., MD ; Llorca, Javier, MD, PhD ; Gonzalez-Juanatey, Carlos, MD, PhD ; Peña-Sagredo, Jose L., MD, PhD ; Martin, Javier, MD, PhD ; Gonzalez-Gay, Miguel A., MD, PhD</creatorcontrib><description>Objectives To investigate the potential association between levels of the erythrocyte sedimentation rate (ESR) and specific clinical features of giant cell arteritis (GCA), in particular, visual loss, in a series of consecutive patients diagnosed with GCA at the reference hospital for a well-defined population. Methods The case records of all biopsy-proven GCA patients diagnosed at the Department of Medicine of Hospital Xeral-Calde (Lugo, Northwest Spain) between 1981 and 2006 were reviewed. Clinical information and laboratory data including ESR at the time of disease diagnosis were assessed. Results Only 10 (3.6%) of the 273 patients had ESR <50 mm/h. Significant differences in the frequency of visual ischemic complications according to different levels of ESR were observed ( P = 0.01), mainly due to an increased frequency of visual ischemic events in patients with ESR between 70 and 100/h at the time of disease diagnosis. Twenty-five (21%) of 120 individuals with ESR values ranging between 70 and 100 mm/h experienced permanent visual loss compared with only 10 (7%) of the remaining 153 patients ( P = 0.0005; OR: 3.76 [95% CI: 1.73-8.19]). An ESR between 70 and 100 mm/h was the best predictor of visual ischemic complications (OR = 2.29 [95% CI: 1.16-4.55]; P = 0.03) and irreversible visual loss (OR = 3.58 [95% CI: 1.51-8.49]; P = 0.004). Conclusions The results from this study show an increased risk of severe ocular complications in biopsy-proven GCA patients presenting with an ESR between 70 and 100 mm/h. Prompt initiation of corticosteroid therapy and close follow-up of these patients is recommended to minimize the risk of irreversible visual loss.</description><identifier>ISSN: 0049-0172</identifier><identifier>EISSN: 1532-866X</identifier><identifier>DOI: 10.1016/j.semarthrit.2007.10.014</identifier><identifier>PMID: 18221984</identifier><identifier>CODEN: SAHRBF</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Albumins - analysis ; Alkaline Phosphatase - blood ; Biological and medical sciences ; Biopsy, Needle ; Blindness - etiology ; Blood Sedimentation ; C-Reactive Protein - analysis ; Diseases of the osteoarticular system ; erythrocyte sedimentation rate ; Female ; giant cell arteritis ; Giant Cell Arteritis - blood ; Giant Cell Arteritis - complications ; Giant Cell Arteritis - drug therapy ; Glucocorticoids - therapeutic use ; Humans ; Ischemia - etiology ; Leukocyte Count ; Male ; Medical sciences ; Ophthalmology ; Platelet Count ; predictors of permanent visual loss ; Rheumatology ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Vision disorders ; visual ischemic complications</subject><ispartof>Seminars in arthritis and rheumatism, 2008-10, Vol.38 (2), p.116-123</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-46cda9a6375bb7fbec074dc4d8a51046dd2d6c841db1d9ebb830ce4a5a1702103</citedby><cites>FETCH-LOGICAL-c457t-46cda9a6375bb7fbec074dc4d8a51046dd2d6c841db1d9ebb830ce4a5a1702103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20751222$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18221984$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lopez-Diaz, Maria J., MD</creatorcontrib><creatorcontrib>Llorca, Javier, MD, PhD</creatorcontrib><creatorcontrib>Gonzalez-Juanatey, Carlos, MD, PhD</creatorcontrib><creatorcontrib>Peña-Sagredo, Jose L., MD, PhD</creatorcontrib><creatorcontrib>Martin, Javier, MD, PhD</creatorcontrib><creatorcontrib>Gonzalez-Gay, Miguel A., MD, PhD</creatorcontrib><title>The Erythrocyte Sedimentation Rate Is Associated with the Development of Visual Complications in Biopsy-Proven Giant Cell Arteritis</title><title>Seminars in arthritis and rheumatism</title><addtitle>Semin Arthritis Rheum</addtitle><description>Objectives To investigate the potential association between levels of the erythrocyte sedimentation rate (ESR) and specific clinical features of giant cell arteritis (GCA), in particular, visual loss, in a series of consecutive patients diagnosed with GCA at the reference hospital for a well-defined population. Methods The case records of all biopsy-proven GCA patients diagnosed at the Department of Medicine of Hospital Xeral-Calde (Lugo, Northwest Spain) between 1981 and 2006 were reviewed. Clinical information and laboratory data including ESR at the time of disease diagnosis were assessed. Results Only 10 (3.6%) of the 273 patients had ESR <50 mm/h. Significant differences in the frequency of visual ischemic complications according to different levels of ESR were observed ( P = 0.01), mainly due to an increased frequency of visual ischemic events in patients with ESR between 70 and 100/h at the time of disease diagnosis. Twenty-five (21%) of 120 individuals with ESR values ranging between 70 and 100 mm/h experienced permanent visual loss compared with only 10 (7%) of the remaining 153 patients ( P = 0.0005; OR: 3.76 [95% CI: 1.73-8.19]). An ESR between 70 and 100 mm/h was the best predictor of visual ischemic complications (OR = 2.29 [95% CI: 1.16-4.55]; P = 0.03) and irreversible visual loss (OR = 3.58 [95% CI: 1.51-8.49]; P = 0.004). Conclusions The results from this study show an increased risk of severe ocular complications in biopsy-proven GCA patients presenting with an ESR between 70 and 100 mm/h. Prompt initiation of corticosteroid therapy and close follow-up of these patients is recommended to minimize the risk of irreversible visual loss.</description><subject>Albumins - analysis</subject><subject>Alkaline Phosphatase - blood</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Blindness - etiology</subject><subject>Blood Sedimentation</subject><subject>C-Reactive Protein - analysis</subject><subject>Diseases of the osteoarticular system</subject><subject>erythrocyte sedimentation rate</subject><subject>Female</subject><subject>giant cell arteritis</subject><subject>Giant Cell Arteritis - blood</subject><subject>Giant Cell Arteritis - complications</subject><subject>Giant Cell Arteritis - drug therapy</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Ischemia - etiology</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Ophthalmology</subject><subject>Platelet Count</subject><subject>predictors of permanent visual loss</subject><subject>Rheumatology</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Vision disorders</subject><subject>visual ischemic complications</subject><issn>0049-0172</issn><issn>1532-866X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqNkkGP0zAQhSMEYrsLfwH5AreUsZM4yQWpW5ZlpZVA7IK4WY49VV3SuHjcopz3j-PQipU4cbI8_t549N5kGeMw58Dl282ccKtDXAcX5wKgTuU58PJJNuNVIfJGyu9PsxlA2ebAa3GWnRNtADiXUD_PzngjBG-bcpY93K-RXYUxtfJmjMju0LotDlFH5wf2RafSDbEFkTcuXSz75eKaxaR6jwfs_W6CmV-xb472umdLv931zvyRE3MDu3R-R2P-OfgDDuza6YQvse_ZIkRM8zt6kT1b6Z7w5em8yL5-uLpffsxvP13fLBe3uSmrOualNFa3WhZ11XX1qkMDdWlNaRtdcSiltcJK05Tcdty22HVNAQZLXWleg-BQXGRvjn13wf_cI0W1dWTSKHpAvyclWwmFbKsENkfQBE8UcKV2wSW_R8VBTQGojXoMQE0BTC8pgCR9dfpj323RPgpPjifg9QnQZHS_Cnowjv5yAuqKCyESd3nkMDlycBgUGYeDSfEENFFZ7_5nmnf_NDG9G1I6_Q8ckTZ-H4bkuOKKhAJ1Ny3MtC9Qp11pKih-AzbmwQE</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Lopez-Diaz, Maria J., MD</creator><creator>Llorca, Javier, MD, PhD</creator><creator>Gonzalez-Juanatey, Carlos, MD, PhD</creator><creator>Peña-Sagredo, Jose L., MD, PhD</creator><creator>Martin, Javier, MD, PhD</creator><creator>Gonzalez-Gay, Miguel A., MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>The Erythrocyte Sedimentation Rate Is Associated with the Development of Visual Complications in Biopsy-Proven Giant Cell Arteritis</title><author>Lopez-Diaz, Maria J., MD ; Llorca, Javier, MD, PhD ; Gonzalez-Juanatey, Carlos, MD, PhD ; Peña-Sagredo, Jose L., MD, PhD ; Martin, Javier, MD, PhD ; Gonzalez-Gay, Miguel A., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-46cda9a6375bb7fbec074dc4d8a51046dd2d6c841db1d9ebb830ce4a5a1702103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Albumins - analysis</topic><topic>Alkaline Phosphatase - blood</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>Blindness - etiology</topic><topic>Blood Sedimentation</topic><topic>C-Reactive Protein - analysis</topic><topic>Diseases of the osteoarticular system</topic><topic>erythrocyte sedimentation rate</topic><topic>Female</topic><topic>giant cell arteritis</topic><topic>Giant Cell Arteritis - blood</topic><topic>Giant Cell Arteritis - complications</topic><topic>Giant Cell Arteritis - drug therapy</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Humans</topic><topic>Ischemia - etiology</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Ophthalmology</topic><topic>Platelet Count</topic><topic>predictors of permanent visual loss</topic><topic>Rheumatology</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Vision disorders</topic><topic>visual ischemic complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lopez-Diaz, Maria J., MD</creatorcontrib><creatorcontrib>Llorca, Javier, MD, PhD</creatorcontrib><creatorcontrib>Gonzalez-Juanatey, Carlos, MD, PhD</creatorcontrib><creatorcontrib>Peña-Sagredo, Jose L., MD, PhD</creatorcontrib><creatorcontrib>Martin, Javier, MD, PhD</creatorcontrib><creatorcontrib>Gonzalez-Gay, Miguel A., MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lopez-Diaz, Maria J., MD</au><au>Llorca, Javier, MD, PhD</au><au>Gonzalez-Juanatey, Carlos, MD, PhD</au><au>Peña-Sagredo, Jose L., MD, PhD</au><au>Martin, Javier, MD, PhD</au><au>Gonzalez-Gay, Miguel A., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Erythrocyte Sedimentation Rate Is Associated with the Development of Visual Complications in Biopsy-Proven Giant Cell Arteritis</atitle><jtitle>Seminars in arthritis and rheumatism</jtitle><addtitle>Semin Arthritis Rheum</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>38</volume><issue>2</issue><spage>116</spage><epage>123</epage><pages>116-123</pages><issn>0049-0172</issn><eissn>1532-866X</eissn><coden>SAHRBF</coden><abstract>Objectives To investigate the potential association between levels of the erythrocyte sedimentation rate (ESR) and specific clinical features of giant cell arteritis (GCA), in particular, visual loss, in a series of consecutive patients diagnosed with GCA at the reference hospital for a well-defined population. Methods The case records of all biopsy-proven GCA patients diagnosed at the Department of Medicine of Hospital Xeral-Calde (Lugo, Northwest Spain) between 1981 and 2006 were reviewed. Clinical information and laboratory data including ESR at the time of disease diagnosis were assessed. Results Only 10 (3.6%) of the 273 patients had ESR <50 mm/h. Significant differences in the frequency of visual ischemic complications according to different levels of ESR were observed ( P = 0.01), mainly due to an increased frequency of visual ischemic events in patients with ESR between 70 and 100/h at the time of disease diagnosis. Twenty-five (21%) of 120 individuals with ESR values ranging between 70 and 100 mm/h experienced permanent visual loss compared with only 10 (7%) of the remaining 153 patients ( P = 0.0005; OR: 3.76 [95% CI: 1.73-8.19]). An ESR between 70 and 100 mm/h was the best predictor of visual ischemic complications (OR = 2.29 [95% CI: 1.16-4.55]; P = 0.03) and irreversible visual loss (OR = 3.58 [95% CI: 1.51-8.49]; P = 0.004). Conclusions The results from this study show an increased risk of severe ocular complications in biopsy-proven GCA patients presenting with an ESR between 70 and 100 mm/h. Prompt initiation of corticosteroid therapy and close follow-up of these patients is recommended to minimize the risk of irreversible visual loss.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>18221984</pmid><doi>10.1016/j.semarthrit.2007.10.014</doi><tpages>8</tpages></addata></record> |
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| subjects | Albumins - analysis Alkaline Phosphatase - blood Biological and medical sciences Biopsy, Needle Blindness - etiology Blood Sedimentation C-Reactive Protein - analysis Diseases of the osteoarticular system erythrocyte sedimentation rate Female giant cell arteritis Giant Cell Arteritis - blood Giant Cell Arteritis - complications Giant Cell Arteritis - drug therapy Glucocorticoids - therapeutic use Humans Ischemia - etiology Leukocyte Count Male Medical sciences Ophthalmology Platelet Count predictors of permanent visual loss Rheumatology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Vision disorders visual ischemic complications |
| title | The Erythrocyte Sedimentation Rate Is Associated with the Development of Visual Complications in Biopsy-Proven Giant Cell Arteritis |
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