Precision of high-throughput single-nucleotide polymorphism genotyping with fingernail DNA: comparison with blood DNA

Such samples need no special attention for transportation and can be preserved dry at room temperature for long periods; however, because fingernail clippings yield fragmented DNA that may be contaminated with certain PCR inhibitors (2), this sample type has seemed unsuitable for analyses requiring...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 2008-10, Vol.54 (10), p.1746-1748
Main Authors: Nakashima, Mitsuko, Tsuda, Masayoshi, Kinoshita, Akira, Kishino, Tatsuya, Kondo, Shinji, Shimokawa, Osamu, Niikawa, Norio, Yoshiura, Koh-Ichiro
Format: Article
Language:English
Subjects:
Accuracy
Deoxyribonucleic acid
DNA
DNA - blood
DNA - genetics
DNA fingerprints
Genetics
Genotype & phenotype
Humans
Life sciences
Molecular weight
Nails - chemistry
Polymorphism
Polymorphism, Single Nucleotide
Reproducibility of Results
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Description
Summary:Such samples need no special attention for transportation and can be preserved dry at room temperature for long periods; however, because fingernail clippings yield fragmented DNA that may be contaminated with certain PCR inhibitors (2), this sample type has seemed unsuitable for analyses requiring high-quality genomic DNA. All authors confirmed they haw contributed to the intellectual content of this paper and haw met the following 3 requirements: (a) significant contributions to the conception and design, acquisition of data, or analysis and interpretation of data; (b) drafting or revising the article for intellectual content; and (c) final approval of the published article.
ISSN:0009-9147
1530-8561
DOI:10.1373/clinchem.2008.108225