Tissue Characterization of Coronary Plaques: Comparison of Integrated Backscatter Intravascular Ultrasound With Virtual Histology Intravascular Ultrasound

Background Integrated backscatter (IB) intravascular ultrasound (IVUS) and IVUS Virtual Histology (VH) have been developed for tissue characterization, but have never been compared directly. The purpose of this study was to compare the overall agreement between IB-IVUS and IVUS-VH in the tissue char...

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Bibliographic Details
Published in:Circulation Journal 2008, Vol.72(10), pp.1631-1639
Main Authors: Okubo, Munenori, Kawasaki, Masanori, Ishihara, Yoshiyuki, Takeyama, Urara, Yasuda, Shinji, Kubota, Tomoki, Tanaka, Shinichiro, Yamaki, Takahiko, Ojio, Shinsuke, Nishigaki, Kazuhiko, Takemura, Genzou, Saio, Masanao, Takami, Tsuyoshi, Fujiwara, Hisayoshi, Minatoguchi, Shinya
Format: Article
Language:English
Subjects:
Atherosclerosis - diagnostic imaging
Atherosclerosis - pathology
Cadaver
Calcinosis - diagnostic imaging
Calcinosis - pathology
Cardiovascular Diseases - diagnostic imaging
Cardiovascular Diseases - pathology
Coronary Disease - diagnostic imaging
Coronary Disease - pathology
Coronary Vessels - diagnostic imaging
Coronary Vessels - pathology
Echocardiography, Three-Dimensional
Fibrosis - diagnostic imaging
Fibrosis - pathology
Humans
Image Processing, Computer-Assisted
Imaging
Plaque
Tissue
Ultrasonics
Ultrasonography, Interventional - methods
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Summary:Background Integrated backscatter (IB) intravascular ultrasound (IVUS) and IVUS Virtual Histology (VH) have been developed for tissue characterization, but have never been compared directly. The purpose of this study was to compare the overall agreement between IB-IVUS and IVUS-VH in the tissue characterization of plaques from the same coronary arterial cross-section. Methods and Results Images were acquired from 46 coronary arteries from 25 cadavers. Of a total of 392 histology/IVUS image pairs, 152 pairs were diagnosed as Stary's type III, IV, Va, Vb and Vc, and compared for IB-IVUS, IVUS-VH and histology. In the qualitative comparison, the overall agreement between histological and IB-IVUS diagnoses was higher (κ=0.81, 95% confidence interval (CI): 0.74-0.89) than that of the IVUS-VH diagnoses (κ=0.66, 95%CI: 0.56-0.75). The % fibrosis area determined by IB-IVUS was significantly correlated with the relative area of fibrosis based on histology (r=0.67, p
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-07-0936