Efficacy of enamel matrix derivatives (Emdogain®) in treatment of replanted teeth - a systematic review based on animal studies

–  The objective of the current systematic review was to evaluate the efficacy of enamel matrix derivative (EMD) (Emdogain®) on healing of replanted or autotransplanted permanent teeth. A review of the published literature [search term: (Emdogain OR enamel matrix derivative OR enamel matrix protein]...

Full description

Saved in:
Bibliographic Details
Published in:Dental traumatology 2008-10, Vol.24 (5), p.498-502
Main Authors: Wiegand, Annette, Attin, Thomas
Format: Article
Language:English
Subjects:
Animals
Dental Enamel Proteins - therapeutic use
Dental Research - methods
Dentistry
Periodontal Ligament - physiology
Root Resorption - prevention & control
Sodium Fluoride - therapeutic use
Tooth Avulsion - surgery
Tooth Replantation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:–  The objective of the current systematic review was to evaluate the efficacy of enamel matrix derivative (EMD) (Emdogain®) on healing of replanted or autotransplanted permanent teeth. A review of the published literature [search term: (Emdogain OR enamel matrix derivative OR enamel matrix protein] AND [avulsion OR replantation OR autotransplantation)] was conducted by two independent investigators according to defined selection criteria. For data extraction of the identified animal studies, the following histomorphometric findings were considered: (i) healed PDL, (ii) surface resorption, (iii) inflammatory resorption and (iv) replacement resorption. The heterogenity of data collection and the small amount of identified publications did not allow for statistical analysis. Four controlled trials (CT) conducted in animals, but no randomized controlled trials (RCT) or clinical controlled trials (CCT) could be received from the systematic search. From the selected studies, two CT gave evidence of EMD treatment to be effective in inducing healing of replanted teeth, while one CT found no differences between EMD treated teeth and controls. Finally, one CT compared EMD and sodium fluoride application, but revealed no differences between the treatments. The data of controlled trials available are limited and conflicting. No firm conclusion regarding the efficacy of EMD application on healing of replanted or autotransplanted permanent teeth can be drawn because of lack of RCT and CCT.
ISSN:1600-4469
1600-9657
DOI:10.1111/j.1600-9657.2008.00662.x