Bordetella pertussis filamentous hemagglutinin delivered by mucosal routes enhances immunoglobulin levels in serum and mucosal fluids

Free Bordetella pertussis filamentous hemagglutinin (FHA) can act as an adjuvant for mucosally administrated antigens. Here, we show that independently of the adjuvant properties of FHA toward an unrelated antigen, total IgG or IgA concentrations in serum and mucosal fluids are enhanced by the admin...

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Published in:FEMS immunology and medical microbiology 2008-10, Vol.54 (1), p.129-136
Main Authors: Poulain-Godefroy, Odile, Vendeville, Catherine, Locht, Camille, Riveau, Gilles
Format: Article
Language:English
Subjects:
Adhesins, Bacterial - administration & dosage
Adhesins, Bacterial - immunology
adjuvant
Adjuvanticity
Adjuvants, Immunologic
Administration, Intranasal
Alveoli
Animals
Animals, Outbred Strains
Antibodies, Bacterial - analysis
Antibodies, Bacterial - blood
Antigens
Bacteriology
Biological and medical sciences
Body Fluids - immunology
Bordetella pertussis
Bordetella pertussis - immunology
Female
FHA
Fundamental and applied biological sciences. Psychology
Gene expression
Hemagglutinins
immunoglobulin
Immunoglobulin A
Immunoglobulin A - analysis
Immunoglobulin A - blood
Immunoglobulin G
Immunoglobulin G - analysis
Immunoglobulin G - blood
Immunoglobulins
Intestine
Intranasal administration
Mice
Microbiology
Miscellaneous
Molecular modelling
Mucosa
mucosal
Mucous Membrane - immunology
Oral administration
Pertussis
Virulence Factors, Bordetella - administration & dosage
Virulence Factors, Bordetella - immunology
Whooping cough
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creator Poulain-Godefroy, Odile
Vendeville, Catherine
Locht, Camille
Riveau, Gilles
description Free Bordetella pertussis filamentous hemagglutinin (FHA) can act as an adjuvant for mucosally administrated antigens. Here, we show that independently of the adjuvant properties of FHA toward an unrelated antigen, total IgG or IgA concentrations in serum and mucosal fluids are enhanced by the administration of FHA. Oral administration of FHA increases both total IgG concentrations in serum and total immunoglobulin concentrations in intestinal lavages. Nasal administration of FHA increases total IgA concentrations in broncho-alveolar lavages. FHA induces Langerhans cell recruitment and MIP-3α mRNA expression within hours after administration. These observations shed a new light on the potential molecular mechanisms of FHA-induced adjuvanticity.
doi_str_mv 10.1111/j.1574-695X.2008.00460.x
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identifier ISSN: 0928-8244
ispartof FEMS immunology and medical microbiology, 2008-10, Vol.54 (1), p.129-136
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2049-632X
language eng
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source Oxford Journals Online
subjects Adhesins, Bacterial - administration & dosage
Adhesins, Bacterial - immunology
adjuvant
Adjuvanticity
Adjuvants, Immunologic
Administration, Intranasal
Alveoli
Animals
Animals, Outbred Strains
Antibodies, Bacterial - analysis
Antibodies, Bacterial - blood
Antigens
Bacteriology
Biological and medical sciences
Body Fluids - immunology
Bordetella pertussis
Bordetella pertussis - immunology
Female
FHA
Fundamental and applied biological sciences. Psychology
Gene expression
Hemagglutinins
immunoglobulin
Immunoglobulin A
Immunoglobulin A - analysis
Immunoglobulin A - blood
Immunoglobulin G
Immunoglobulin G - analysis
Immunoglobulin G - blood
Immunoglobulins
Intestine
Intranasal administration
Mice
Microbiology
Miscellaneous
Molecular modelling
Mucosa
mucosal
Mucous Membrane - immunology
Oral administration
Pertussis
Virulence Factors, Bordetella - administration & dosage
Virulence Factors, Bordetella - immunology
Whooping cough
title Bordetella pertussis filamentous hemagglutinin delivered by mucosal routes enhances immunoglobulin levels in serum and mucosal fluids
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