Associations with multiple pituitary hormone deficiency in patients with an ectopic posterior pituitary gland

Summary Introduction  The presence of an ectopic posterior pituitary gland (EPP) on magnetic resonance imaging (MRI) is associated with hypopituitarism with one or more hormone deficiencies. We aimed to identify risk factors for having multiple pituitary hormone deficiency (MPHD) compared to isolate...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2008-10, Vol.69 (4), p.597-602
Main Authors: Murray, P. G., Hague, C., Fafoula, O., Patel, L., Raabe, A. L., Cusick, C., Hall, C. M., Wright, N. B., Amin, R., Clayton, P. E.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child
Child, Preschool
Choristoma - complications
Choristoma - epidemiology
Cohort Studies
Endocrinopathies
Female
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Humans
Hypopituitarism - complications
Hypopituitarism - epidemiology
Hypothalamic Diseases - complications
Hypothalamic Diseases - epidemiology
Hypothalamus. Hypophysis. Epiphysis (diseases)
Infant
Infant, Newborn
Male
Medical sciences
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Pituitary Gland, Posterior
Pituitary Hormones - deficiency
Pregnancy
Prevalence
Vertebrates: endocrinology
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Summary:Summary Introduction  The presence of an ectopic posterior pituitary gland (EPP) on magnetic resonance imaging (MRI) is associated with hypopituitarism with one or more hormone deficiencies. We aimed to identify risk factors for having multiple pituitary hormone deficiency (MPHD) compared to isolated growth hormone deficiency (IGHD) in patients with an EPP. Methods  In 67 patients (45 male) with an EPP on MRI, the site (hypothalamic vs. stalk) and surface area (SA) [ × (maximum diameter/2) × (maximum height/2), mm2] of the EPP were recorded and compared in patients with IGHD and MPHD in relation to clinical characteristics. Results  In MPHD (n = 32) compared to IGHD (n = 35) patients: age of presentation was younger (1·4 [0·1–10·7]vs. 4·0 [0·1–11·3] years, P = 0·005), major incidents during pregnancy were increased (47%vs. 20%, P = 0·02) as were admissions to a neonatal intensive care unit (NICU) (60%vs. 26%, P = 0·04), whilst EPP SA was lower (12·3 [2·4–34·6]vs. 25·7 [6·9–48·2] mm2, P 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2008.03236.x