L-ascorbic acid improves the serum folate response to an oral dose of [6S]-5-methyltetrahydrofolic acid in healthy men

Objective: To investigate the effect of simultaneous administration of [6S]-5-methyltetrahydrofolic acid ([6S]-5-CH3H4PteGlu) with L-ascorbic acid (L-AA) on serum folate concentrations in healthy male subjects. Subjects and methods: A total of nine healthy male volunteers were recruited. Serum folat...

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Bibliographic Details
Published in:European journal of clinical nutrition 2008-10, Vol.62 (10), p.1224-1230
Main Authors: Verlinde, P.H.C.J, Oey, I, Hendrickx, M.E, Loey, A.M. van, Temme, E.H.M
Format: Article
Language:English
Subjects:
6S-5-methyltetrahydrofolic acid
Acids
Administration, Oral
Adult
adults
Antioxidants - pharmacology
Area Under Curve
Ascorbic acid
Ascorbic Acid - pharmacology
Bioavailability
Biological Availability
Biomarkers - blood
blood chemistry
Clinical Nutrition
Cross-Over Studies
Dietary supplements
dosage
Dosage and administration
Dose-Response Relationship, Drug
Epidemiology
Folic acid
Folic Acid - blood
Folic Acid - pharmacokinetics
Humans
Internal Medicine
Intestinal Absorption - drug effects
Male
Medicine
Medicine & Public Health
men
Metabolic Diseases
nutrient availability
nutrient uptake
nutritional status
oral administration
original-article
Physiology
Properties
Public Health
Tetrahydrofolates - pharmacokinetics
Vitamin B
Vitamin B Complex - blood
Vitamin B Complex - pharmacokinetics
Vitamin C
Young Adult
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Summary:Objective: To investigate the effect of simultaneous administration of [6S]-5-methyltetrahydrofolic acid ([6S]-5-CH3H4PteGlu) with L-ascorbic acid (L-AA) on serum folate concentrations in healthy male subjects. Subjects and methods: A total of nine healthy male volunteers were recruited. Serum folate concentrations were measured before and up to 8 h after administration of each treatment (1) placebo, (2) 343 micrograms [6S]-5-CH3H4PteGlu), (3) 343 micrograms [6S]-5-CH3H4PteGlu) with 289.4 mg L-AA and (4) 343 micrograms [6S]-5-CH3H4PteGlu) with 973.8 mg L-AA (n=10 samples per treatment). Results: Serum folate concentrations significantly increased compared with baseline values, starting from 30 min after [6S]-5-CH3H4PteGlu administration and remained significantly higher than baseline values during the first 6 h for treatments 3 and 4, and during the first 4 h for treatment 2. Maximal serum folate responses were observed between 0.5 and 1.5 h after [6S]-5-CH3H4PteGlu consumption and significantly differed between treatments 2 and 4 (P
ISSN:0954-3007
1476-5640
DOI:10.1038/sj.ejcn.1602840