Using single photon emission tomography (SPECT) and positron emission tomography (PET) to trace the distribution of muscarinic acetylcholine receptor (MACHR) binding radioligands

Two [ 18F] labeled ligands for the mAChR were prepared and evaluated in rodents and nonhuman primates. The properties of both compounds, one an agonist and the other an antagonist, were consistent with M 2 subtype specificity.

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Bibliographic Details
Published in:Life sciences (1973) 1999, Vol.64 (6), p.511-518
Main Authors: Kiesewetter, Dale O., Carson, Richard E., Jagoda, Elaine M., Herscovitch, Peter, Eckelman, William C.
Format: Article
Language:English
Subjects:
Animals
Benzilates - metabolism
Benzilates - pharmacokinetics
Brain - diagnostic imaging
Brain - metabolism
Fluorine Radioisotopes
Heart - diagnostic imaging
Humans
Ligands
mAChR binding radioligands
Muscarinic Agonists - metabolism
Muscarinic Agonists - pharmacokinetics
Muscarinic Antagonists - metabolism
Muscarinic Antagonists - pharmacokinetics
Myocardium - metabolism
PET
Physostigmine - metabolism
Pyridines - antagonists & inhibitors
Pyridines - metabolism
Pyridines - pharmacokinetics
Quinuclidines - metabolism
Quinuclidines - pharmacokinetics
Radioactive Tracers
Receptors, Muscarinic - metabolism
SPECT
Thiazoles - antagonists & inhibitors
Thiazoles - metabolism
Thiazoles - pharmacokinetics
Tomography, Emission-Computed
Tomography, Emission-Computed, Single-Photon
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Description
Summary:Two [ 18F] labeled ligands for the mAChR were prepared and evaluated in rodents and nonhuman primates. The properties of both compounds, one an agonist and the other an antagonist, were consistent with M 2 subtype specificity.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(98)00595-5