Pediatric intramedullary spinal cord tumors : Critical review of the literature

The objective of this review was to analyze the literature on the management of intramedullary spinal cord tumors to determine whether enough information was available for treatment guidelines to be established. Using standard computerized search techniques, databases containing medical literature w...

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Bibliographic Details
Published in:Child's nervous system 1999, Vol.15 (1), p.17-28
Main Authors: NADKARNI, T. D, REKATE, H. L
Format: Article
Language:English
Subjects:
Astrocytoma - pathology
Astrocytoma - therapy
Biological and medical sciences
Child
Child, Preschool
Guidelines as Topic
Humans
Medical sciences
Medulla Oblongata - pathology
Medulla Oblongata - surgery
Neurology
Spinal Cord Neoplasms - pathology
Spinal Cord Neoplasms - therapy
Tumors of the nervous system. Phacomatoses
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Summary:The objective of this review was to analyze the literature on the management of intramedullary spinal cord tumors to determine whether enough information was available for treatment guidelines to be established. Using standard computerized search techniques, databases containing medical literature were queried for keywords related to intramedullary spinal cord tumors, beginning in 1966. Of the 445 articles published in English and with potential relevance, only 75 articles were included in the final analyses. Based on the strength of their recommendations for the treatment of this controversial condition, articles were divided into class I, class II and class III data. There were no class I studies related to any aspect of the treatment of intramedullary spinal cord tumors. Based on this critical review of literature, gross total removal of an ependymoma confirmed by immediate postoperative magnetic resonance imaging and adjunctive treatment for high-grade tumors using radiotherapy, with or without chemotherapy, can be recommended as standards of therapy. With the strength of a guideline, radiotherapy should be withheld after gross total removal of intramedullary ependymomas and radical resection of low-grade intramedullary astrocytomas. The use of intraoperative ultrasonography and evoked potentials, important surgical adjuncts, can also be considered guidelines. The radical resection of intramedullary low-grade astrocytomas is an option.
ISSN:0256-7040
1433-0350
DOI:10.1007/s003810050321