The neurochip: a new multielectrode device for stimulating and recording from cultured neurons

The neurochip is a silicon micromachined device upon which cultured mammalian neurons can be continuously and individually monitored and stimulated. The neurochip is based upon a 4×4 array of metal electrodes, each of which has a caged well structure designed to hold a single mature cell body while...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuroscience methods 1999-02, Vol.87 (1), p.45-56
Main Authors: Maher, MichaelP, Pine, Jerome, Wright, John, Tai, Yu-Chong
Format: Article
Language:English
Subjects:
Algorithms
Animals
Biological and medical sciences
Cells, Cultured
Computer Simulation
Electronics
Evoked Potentials - physiology
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Microcomputers
Microelectrodes
Microscopy, Electron, Scanning
Microscopy, Phase-Contrast
Models, Neurological
Neurons - physiology
Rats
Silicon
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The neurochip is a silicon micromachined device upon which cultured mammalian neurons can be continuously and individually monitored and stimulated. The neurochip is based upon a 4×4 array of metal electrodes, each of which has a caged well structure designed to hold a single mature cell body while permitting normal outgrowth of neural processes. We demonstrate that this device is capable of maintaining cell survival, and that the electrodes can both record and stimulate electrical activity in individual cells with no crosstalk between channels.
ISSN:0165-0270
1872-678X
DOI:10.1016/S0165-0270(98)00156-3