Effect of acute testosterone on myocardial ischemia in men with coronary artery disease

The effect of acute testosterone administration on exercise-induced myocardial ischemia was assessed in 14 men with coronary artery disease and low plasma testosterone concentrations in a study of randomized, double-blind, crossover design. Testosterone increased time to 1-mm ST-segment depression c...

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Bibliographic Details
Published in:The American journal of cardiology 1999-02, Vol.83 (3), p.437-439
Main Authors: Webb, Carolyn M., Adamson, Dawn L., de Zeigler, Dominique, Collins, Peter
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular disease
Coronary Angiography
Coronary Artery Disease - blood
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - drug therapy
Coronary heart disease
Double-Blind Method
Electrocardiography - drug effects
Estradiol - blood
Exercise Test
Follow-Up Studies
Heart
Hormones
Humans
Injections, Intravenous
Male
Medical research
Medical sciences
Men
Middle Aged
Myocardial Ischemia - blood
Myocardial Ischemia - diagnosis
Myocardial Ischemia - drug therapy
Testosterone - administration & dosage
Testosterone - blood
Testosterone - therapeutic use
Treatment Outcome
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Summary:The effect of acute testosterone administration on exercise-induced myocardial ischemia was assessed in 14 men with coronary artery disease and low plasma testosterone concentrations in a study of randomized, double-blind, crossover design. Testosterone increased time to 1-mm ST-segment depression compared with placebo by 66 (15 to 117) seconds (p = 0.016), suggesting a beneficial effect of testosterone on myocardial ischemia in these patients.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(98)00880-7