Cloning of Aire, the mouse homologue of the autoimmune regulator (AIRE) gene responsible for autoimmune polyglandular syndrome type 1 (APS1)

The human autoimmune regulator gene (AIRE), responsible for autoimmune polyglandular syndrome Type 1 (APS1), has recently been identified by positional cloning. Here we report the cloning of Aire, the mouse homologue of AIRE, and the characterization of its genomic structure. The complete Aire gene...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1999-02, Vol.55 (3), p.322-326
Main Authors: WANG, C.-Y, SHI, J.-D, DAVOODI-SEMIROMI, A, SHE, J.-X
Format: Article
Language:English
Subjects:
AIRE Protein
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
Cloning, Molecular
DNA Primers
Fundamental and applied biological sciences. Psychology
Genes. Genome
Humans
Mice
Models, Genetic
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Polyendocrinopathies, Autoimmune - genetics
Reverse Transcriptase Polymerase Chain Reaction
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Transcription Factors - genetics
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Summary:The human autoimmune regulator gene (AIRE), responsible for autoimmune polyglandular syndrome Type 1 (APS1), has recently been identified by positional cloning. Here we report the cloning of Aire, the mouse homologue of AIRE, and the characterization of its genomic structure. The complete Aire gene is contained in 14 exons and encodes a protein of 552 amino acids. The coding region shares 77% nucleotide homology and 71% protein homology with human AIRE. As in its human homologue, Aire contains two PHD-type zinc-finger motifs, suggesting that the Aire protein may act as a transcription regulator.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1998.5656