Does angiotensin-converting enzyme polymorphism influence the clinical manifestation and progression of heart failure in patients with dilated cardiomyopathy?

To evaluate the role of angiotensin-converting enzyme (ACE) polymorphism on the development of end-stage dilated cardiomyopathy, the ACE gene polymorphism of 90 patients after heart transplantation because of this disease was compared with the population sample. No difference in gene frequencies was...

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Bibliographic Details
Published in:The American journal of cardiology 1999-02, Vol.83 (3), p.461-462
Main Authors: Vančura, Vlastimil, Hubáček, Jaroslav, Málek, Ivan, Gebauerová, Marie, Pit’ha, Jan, Dorazilová, Zora, Langová, Martina, Želı́zko, Michael, Poledne, Rudolf
Format: Article
Language:English
Subjects:
Adult
Alleles
Biological and medical sciences
Cardiology. Vascular system
Cardiomyopathy, Dilated - complications
Cardiomyopathy, Dilated - enzymology
Cardiomyopathy, Dilated - surgery
Disease Progression
DNA - biosynthesis
Female
Follow-Up Studies
Gene Frequency
Genetic Markers
Genotype
Heart
Heart Failure - enzymology
Heart Failure - etiology
Heart Failure - surgery
Heart Transplantation
Humans
Male
Medical sciences
Middle Aged
Myocarditis. Cardiomyopathies
Peptidyl-Dipeptidase A - genetics
Polymorphism, Genetic
Prognosis
Retrospective Studies
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Summary:To evaluate the role of angiotensin-converting enzyme (ACE) polymorphism on the development of end-stage dilated cardiomyopathy, the ACE gene polymorphism of 90 patients after heart transplantation because of this disease was compared with the population sample. No difference in gene frequencies was found, but when compared with the population sample there were fewer ID heterozygotes detected; no significant influence of ACE polymorphism on the course of the disease before transplantation was found.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(98)00889-3