The contributory role of interstitial water in Gd-DTPA-enhanced MRI in myocardial infarction

We studied the mechanism underlying regional enhancement of myocardial infarction using T1‐weighted MRI with gadolinium (Gd)‐DTPA. Anterior myocardial infarction (MI) was produced by left anterior descending coronary artery ligation in three groups of rats as follows: 60 minutes occlusion (occlusion...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 1999-02, Vol.9 (2), p.215-219
Main Authors: Inoue, Shin-ichi, Murakami, Yo, Ochiai, Koichi, Kitamura, Jun, Ishibashi, Yutaka, Kawamitsu, Hideaki, Sugimura, Kazuro, Shimada, Toshio
Format: Article
Language:English
Subjects:
Animals
Body Water
Contrast Media
Extracellular Space
Gadolinium DTPA
Gd-DTPA
interstitial edema
Magnetic Resonance Imaging - methods
Male
MRI
Myocardial Infarction - pathology
Myocardial Reperfusion Injury - pathology
Myocardium - pathology
Rats
Rats, Sprague-Dawley
reperfusion
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Summary:We studied the mechanism underlying regional enhancement of myocardial infarction using T1‐weighted MRI with gadolinium (Gd)‐DTPA. Anterior myocardial infarction (MI) was produced by left anterior descending coronary artery ligation in three groups of rats as follows: 60 minutes occlusion (occlusion group, N = 6), 60 minutes occlusion plus 120 minutes reperfusion (reperfusion group, N = 8), and sham‐operated (control, N = 6). In Gd‐DTPA‐enhanced MRI, MI was demarcated as a hypoenhanced region in the occlusion group and as a homogeneous hyperenhanced region in the reperfusion group. Both Gd‐DTPA tissue concentration and tissue water content in the anterior wall were highest in the reperfusion group (P < 0.05), a finding suggestive of microscopically observed interstitial edema. The data suggest that regional accumulation of Gd‐DTPA in the reperfused group can be explained by increased interstitial water content, contributing to the delayed washout of the water‐soluble contrast medium. J. Magn. Reson. Imaging 1999;9:215–219. © 1999 Wiley‐Liss, Inc.
ISSN:1053-1807
1522-2586
DOI:10.1002/(SICI)1522-2586(199902)9:2<215::AID-JMRI10>3.0.CO;2-#