Molecular cloning and developmental expression of a zebrafish axonal glycoprotein similar to TAG-1

TAG-1 is a mammalian cell adhesion molecule of the immunoglobulin superfamily that is expressed transiently by a subset of neurons and serves as a fertile substrate for neurite outgrowth in vitro (Furley, A.H., Morton, S.B., Manalo, D., Karagogeos, S., Dodd, H., Jessell, T.M., 1990 The axonal glycop...

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Bibliographic Details
Published in:Mechanisms of development 1999-02, Vol.80 (2), p.197-201
Main Authors: Warren, James T., Chandrasekhar, Anand, Kanki, John P., Rangarajan, Radha, Furley, Andrew J., Kuwada, John Y.
Format: Article
Language:English
Subjects:
Animals
Axon pathfinding
Brain
Branchiomotor neuron
Cell adhesion molecule
Cell Adhesion Molecules, Neuronal
Central Nervous System - embryology
Central Nervous System - metabolism
Cloning, Molecular
Contactin 2
Embryo, Nonmammalian - metabolism
Embryo, Nonmammalian - ultrastructure
Eye
Gene expression
Gene Expression Regulation, Developmental
Glycoprotein
Growth cone
In Situ Hybridization
Lateral line
Membrane Glycoproteins - biosynthesis
Membrane Glycoproteins - genetics
Membrane Glycoproteins - physiology
Morphogenesis - genetics
Neural crest
Neuronal development
Neurons - metabolism
Sequence Homology, Amino Acid
Spinal cord
tag1
Trigeminal ganglion
Zebrafish
Zebrafish - embryology
Zebrafish - genetics
Zebrafish - metabolism
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Summary:TAG-1 is a mammalian cell adhesion molecule of the immunoglobulin superfamily that is expressed transiently by a subset of neurons and serves as a fertile substrate for neurite outgrowth in vitro (Furley, A.H., Morton, S.B., Manalo, D., Karagogeos, S., Dodd, H., Jessell, T.M., 1990 The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth promoting activity. Cell 61, 157–170). In order to examine the in vivo function of this molecule, we have cloned a zebrafish tag1-like cDNA and analyzed its expression patterns. tag1 is expressed transiently by specific subsets of neurons when they are projecting their axons or when they are migrating. The specific and dynamic pattern of expression of zebrafish tag1 is consistent with its proposed role in axon guidance and cell migration.
ISSN:0925-4773
1872-6356
DOI:10.1016/S0925-4773(98)00215-9