Diastolic Dysfunction and Collagen Structure in Canine Pacing-Induced Heart Failure

Heart failure is characterized not only by systolic, but also by diastolic dysfunction. The present study tested whether or not diastolic dysfunction is associated with changes in tissue properties and collagen network structure. Heart failure was induced in seven chronically instrumented, conscious...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 1999-01, Vol.31 (1), p.179-192
Main Authors: Neumann, T., Vollmer, A., Schaffner, Th, Hess, O.M., Heusch, G.
Format: Article
Language:English
Subjects:
Animals
Cardiac Pacing, Artificial
Collagen
Collagen - analysis
Collagen - physiology
Conscious dogs
Diastole
Dogs
Heart - anatomy & histology
Heart - physiology
Heart failure
Hemodynamics
Left ventricular function
Left ventricular stiffness
Stroke Volume - physiology
Ventricular Dysfunction, Left - metabolism
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Summary:Heart failure is characterized not only by systolic, but also by diastolic dysfunction. The present study tested whether or not diastolic dysfunction is associated with changes in tissue properties and collagen network structure. Heart failure was induced in seven chronically instrumented, conscious dogs by rapid left ventricular pacing (250 min−1). After 2–5 [mean: 4±1 (s.d.)] weeks pacing, heart failure was apparent from clinical symptoms (ascites, cachexia, edema, exercise intolerance) and hemodynamic parameters (significant increases of heart rate and left ventricular end-diastolic pressure and decreases of left ventricular maximal pressure, dP/dtmaxand systolic wall thickening). The left ventricle was dilated, as indicated by a decrease of end-diastolic wall thickness (6.3±2.0v7.2±2.1 mmP
ISSN:0022-2828
1095-8584
DOI:10.1006/jmcc.1998.0853