The neurotrophins NGF and NT-3 reduce sensory neuronal loss in adult rat after peripheral nerve lesion

The effect of three different neurotrophins on axotomy-induced death of adult rat sensory neurons was examined. The ventral branch of the 13th spinal nerve was transected and the corresponding neurons in the 13th thoracic (T13) dorsal root ganglion (DRG) were pre-labelled with Fast Blue (FB). For a...

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Bibliographic Details
Published in:Neuroscience letters 1999-02, Vol.262 (1), p.29-32
Main Authors: Ljungberg, Christina, Novikov, Lev, Kellerth, Jan-Olof, Ebendal, Ted, Wiberg, Mikael
Format: Article
Language:English
Subjects:
Animals
Axotomy
Biological and medical sciences
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - administration & dosage
Cell Death - drug effects
Cell physiology
Dorsal root ganglia
Fast blue
Female
Fundamental and applied biological sciences. Psychology
Infusion Pumps
Injections, Spinal
Molecular and cellular biology
Nerve Growth Factors - administration & dosage
Nerve Growth Factors - pharmacology
Nerve Growth Factors - therapeutic use
Neurons, Afferent - drug effects
Neurons, Afferent - pathology
Neurotrophin 3
Peripheral nerve
Peripheral Nerves - drug effects
Peripheral Nerves - physiology
Rats
Rats, Sprague-Dawley
Responses to growth factors, tumor promotors, other factors
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Summary:The effect of three different neurotrophins on axotomy-induced death of adult rat sensory neurons was examined. The ventral branch of the 13th spinal nerve was transected and the corresponding neurons in the 13th thoracic (T13) dorsal root ganglion (DRG) were pre-labelled with Fast Blue (FB). For a period of 4 weeks, animals received either no treatment, continuous intrathecal infusion of phosphate buffer, nerve growth factor (NGF), neurotrophin-3 (NT-3), or brain-derived neurotrophic factor (BDNF). Labelled neurons remaining after this period were counted. Inert, or no treatment, resulted in extensive loss of the DRG neurons. BDNF application was virtually non-effective, while NGF or NT-3 resulted in a greater number of FB-labelled neurons compared to normal controls. This suggests that NGF and NT-3 are survival factors for adult sensory neurons with a therapeutic potential in peripheral nerve injuries.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(99)00040-3