New Jaspamide Derivatives from the Marine Sponge Jaspis splendans Collected in Vanuatu

Two new jaspamide derivatives (1 and 2) along with jaspamide have been isolated from the marine sponge Jaspis splendans collected in Vanuatu. Their chemical structures were determined from 1D and 2D NMR studies and MS data. These two compounds inhibited the in vitro growth of the NSCLC-N6 human tumo...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1999-02, Vol.62 (2), p.332-334
Main Authors: Zampella, Angela, Giannini, Clelia, Debitus, Cécile, Roussakis, Christos, D'Auria, Maria Valeria
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Biological and medical sciences
Carcinoma, Non-Small-Cell Lung - pathology
Cell Division - drug effects
Drug Screening Assays, Antitumor
General pharmacology
Humans
Jaspis splendans
Lung Neoplasms - pathology
Marine
Medical sciences
Molecular Structure
Peptides, Cyclic - chemistry
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porifera
Porifera - chemistry
Spectrum Analysis
Tumor Cells, Cultured
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Summary:Two new jaspamide derivatives (1 and 2) along with jaspamide have been isolated from the marine sponge Jaspis splendans collected in Vanuatu. Their chemical structures were determined from 1D and 2D NMR studies and MS data. These two compounds inhibited the in vitro growth of the NSCLC-N6 human tumor cell lines with IC50 values in the μg/mL range.
ISSN:0163-3864
1520-6025
DOI:10.1021/np9803225