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Influenza-Associated Morbidity and Mortality in Young and Middle-Aged Women
CONTEXT Data are limited on rates of influenza-associated hospitalizations and deaths among adults younger than 65 years. OBJECTIVE To quantify serious morbidity and mortality from influenza for women younger than 65 years with and without certain chronic medical conditions, including human immunode...
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Published in: | JAMA : the journal of the American Medical Association 1999-03, Vol.281 (10), p.901-907 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | CONTEXT Data are limited on rates of influenza-associated
hospitalizations and deaths among adults younger than 65 years. OBJECTIVE To quantify serious morbidity and mortality from
influenza for women younger than 65 years with and without certain
chronic medical conditions, including human immunodeficiency virus
infection. DESIGN Retrospective cohort study. SETTING AND POPULATION Women aged 15 to 64 years enrolled in the
Tennessee Medicaid program from 1974 to 1993. MAIN OUTCOME MEASURE All hospitalizations for and deaths from
pneumonia, influenza, and other selected acute cardiopulmonary
conditions for women with and without selected chronic medical
conditions during 19 consecutive years. Influenza-attributable risk was
calculated by subtracting event rates during peri-influenza season
(November through April of each year when influenza virus was not
circulating) from adjusted rates during influenza season (November
through April when influenza virus was circulating). RESULTS During the 19 years of the study, we identified
53,607 acute cardiopulmonary hospitalizations and deaths. Rates
of such events were consistently higher during influenza seasons than
peri-influenza seasons. Among high-risk women, the estimated annual
excess was 23 hospitalizations and deaths per 10,000
women aged 15 to 44 years and 58 such events per 10,000 women
aged 45 to 64 years. The estimated annual excess mortality due to
influenza was 2 deaths per 10,000 high-risk women for both age
groups combined. Among women with no identified high-risk conditions,
estimated annual excess hospitalizations and deaths were 4 and 6 per
10,000 women aged 15 to 44 and 45 to 64 years, respectively. CONCLUSIONS Women younger than 65 years with certain chronic
medical conditions experience substantial morbidity and mortality from
acute cardiopulmonary events during influenza season. More effective
targeting of these populations for annual influenza immunization is
warranted. |
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ISSN: | 0098-7484 1538-3598 |
DOI: | 10.1001/jama.281.10.901 |